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Table 4 Statistically significant latent structure, direct and indirect effects on physical QOL

From: Quality of life and associated factors among people receiving second-line anti-retroviral therapy in Johannesburg, South Africa

Latent variables Estimate STD SE P-value
General health perception → physical/functional QOL 1.220 0.452 0.148 < 0.001
Pain → physical/functional QOL 1.613 0.438 0.206 < 0.001
Vigorous activities limited → physical/functional QOL 1 0.931   
Normal activities limited → physical/functional QOL 0.953 0.925 0.034 < 0.001
Daily activities limited → physical/functional QOL 0.659 0.836 0.032 < 0.001
Role function limited → physical/functional QOL 0.959 0.974 0.028 < 0.001
Role function at work → physical/functional QOL 1.008 0.999 0.025 < 0.001
Interference of normal social activities → physical/functional QOL 0.968 0.423 0.120 < 0.001
Family activities limited → physical/functional QOL 0.525 0.413 0.069 < 0.001
Fatigue → physical/functional QOL 0.515 0.295 0.114 < 0.001
Vitality → physical/functional QOL 0.551 0.262 0.105 < 0.001
Direct effects
 Sex → alcohol use 0.124 0.118 0.061 0.044
 Sex → adverse events 0.300 0.130 0.1.22 0.014
 Pill burden → physical/functional QOL − 0.020 − 0.219 0.006 0.001
 Age → pill burden 0.047 0.156 0.020 0.020
 Treatment → pill burden 0.722 0.122 0.311 0.029
 Sex → pill burden 1.298 0.185 0.401 0.001
 Pill burden → severity of adverse events 0.059 0.356 0.011 < 0.001
Indirect effects
 Age → pill burden → severity of adverse events 0.003 0.056 0.001 0.030
 Treatment regimen → pill burden → severity of adverse events 0.043 0.043 0.020 0.032
 Sex → pill burden → severity of adverse events 0.077 0.066 0.028 0.006
 Age → pill burden → physical/functional QOL − 0.0009 − 0.063 0.0004 0.054
 Treatment regimen → pill burden → physical/functional QOL − 0.014 − 0.097 0.007 0.055
 Sex → pill burden → physical/functional QOL − 0.025 − 0.034 0.011 0.019
Correlations
 Number of adverse events ↔ severity of adverse events 0.325 0.537 0.040 < 0.001
 Number of adverse events ↔ pill burden 1.351 0.513 0.210 < 0.001
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BMC Infectious Diseases

ISSN: 1471-2334

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