Skip to main content

Table 2 Sensitivity, specificity, positive and negative predictive values for scores from selected articles with given cut-offs

From: Clinical prediction models for diagnosis of COVID-19 among adult patients: a validation and agreement study

  qRT-PCR test
All Positive Negative Diagnostic test results (Rubin’s rules)
Total n (%) Total n (%) Total n (%) Se (CI95%) Sp (95CI%) PPV (95CI%) NPV (95CI%)
Vieceli et al.   1475   492   983      
 Cut-off value  ≥ 5   847 (57.4)   418 (85.0)   429 (43.6) 0.84 (0.80–0.87) 0.57 (0.54–0.60) 0.48 (0.45–0.51) 0.88 (0.86–0.91)
Tordjman et al.   1618   519   1099      
 Cut-off value  ≥ 0   1618 (100.0)   519 (100.0)   1099 (100.0) / / / /
   ≥ 1   1427 (88.2)   503 (96.9)   924 (84.1) 0.97 (0.95–0.98) 0.16 (0.14–0.18) 0.35 (0.33–0.38) 0.92 (0.87–0.95)
   ≥ 2   1224 (75.6)   475 (91.5)   749 (68.2) 0.92 (0.89–0.94) 0.32 (0.29–0.35) 0.39 (0.36–0.42) 0.89 (0.85–0.92)
   ≥ 3   952 (58.8)   419 (80.7)   533 (48.5) 0.81 (0.77–0.84) 0.52 (0.49–0.54) 0.44 (0.41–0.47) 0.85 (0.82–0.88)
   ≥ 4   649 (40.1)   330 (63.6)   319 (29.0) 0.64 (0.59–0.68) 0.71 (0.68–0.74) 0.51 (0.47–0.55) 0.80 (0.78–0.83)
   ≥ 5   204 (12.6)   145 (27.9)   59 (5.4) 0.28 (0.24–0.32) 0.95 (0.93–0.96) 0.71 (0.64–0.77) 0.74 (0.71–0.76)
Kurstjens et al.   1472   489   983      
 Cut-off value  > 2   1123 (76.3)   468 (95.7)   655 (66.6) 0.96 (0.94–0.98) 0.33 (0.30–0.36) 0.40 (0.38–0.43) 0.94 (0.92–0.97)
   > 3   1010 (68.6)   457 (93.5)   553 (56.3) 0.93 (0.91–0.95) 0.44 (0.41–0.47) 0.44 (0.41–0.47) 0.93 (0.91–0.95)
   > 4   884 (60.1)   443 (90.6)   441 (44.9) 0.90 (0.87–0.93) 0.55 (0.52–0.58) 0.49 (0.45–0.52) 0.92 (0.90–0.94)
   ≥ 5   756 (51.4)   423 (86.5)   333 (33.9) 0.86 (0.83–0.89) 0.66 (0.63–0.69) 0.54 (0.51–0.58) 0.91 (0.89–0.93)
   ≥ 9   440 (29.9)   333 (68.1)   107 (10.9) 0.66 (0.62–0.71) 0.89 (0.87–0.91) 0.74 (0.70–0.85) 0.85 (0.83–0.87)
   ≥ 10   355 (24.1)   281 (57.5)   74 (7.5) 0.56 (0.52–0.60) 0.92 (0.91–0.94) 0.78 (0.74–0.82) 0.82 (0.80–0.84)
   ≥ 11   275 (18.7)   229 (46.8)   46 (4.7) 0.45 (0.41–0.50) 0.95 (0.94–0.96) 0.82 (0.78–0.87) 0.79 (0.76–0.81)
   ≥ 12   200 (13.6)   176 (36.0)   24 (2.4) 0.35 (0.30–0.39) 0.98 (0.97–0.99) 0.87 (0.82–0.92) 0.76 (0.74–0.78)
Aldobyany et al.   502   224   278      
 Cut-off value  ≥ 3   384 (76.5)   188 (83.9)   196 (70.5) 0.81 (0.77–0.84) 0.28 (0.25–0.30) 0.35 (0.32–0.37) 0.75 (0.71–0.80)
   ≥ 4   300 (59.8)   168 (75.0)   132 (47.5) 0.69 (0.65–0.73) 0.47 (0.44–0.50) 0.38 (0.35–0.41) 0.76 (0.73–0.80)
Nakakubo et al.   1615   519   1096      
 Cut-off value  > 5   762 (47.2)   397 (76.5)   365 (33.3) 0.78 (0.74–0.82) 0.64 (0.61–0.67) 0.51 (0.47–0.54) 0.86 (0.84–0.89)