qRT-PCR test | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
All | Positive | Negative | Diagnostic test results (Rubin’s rules) | ||||||||
Total | n (%) | Total | n (%) | Total | n (%) | Se (CI95%) | Sp (95CI%) | PPV (95CI%) | NPV (95CI%) | ||
Vieceli et al. | 1475 | 492 | 983 | ||||||||
Cut-off value | ≥ 5 | 847 (57.4) | 418 (85.0) | 429 (43.6) | 0.84 (0.80–0.87) | 0.57 (0.54–0.60) | 0.48 (0.45–0.51) | 0.88 (0.86–0.91) | |||
Tordjman et al. | 1618 | 519 | 1099 | ||||||||
Cut-off value | ≥ 0 | 1618 (100.0) | 519 (100.0) | 1099 (100.0) | / | / | / | / | |||
≥ 1 | 1427 (88.2) | 503 (96.9) | 924 (84.1) | 0.97 (0.95–0.98) | 0.16 (0.14–0.18) | 0.35 (0.33–0.38) | 0.92 (0.87–0.95) | ||||
≥ 2 | 1224 (75.6) | 475 (91.5) | 749 (68.2) | 0.92 (0.89–0.94) | 0.32 (0.29–0.35) | 0.39 (0.36–0.42) | 0.89 (0.85–0.92) | ||||
≥ 3 | 952 (58.8) | 419 (80.7) | 533 (48.5) | 0.81 (0.77–0.84) | 0.52 (0.49–0.54) | 0.44 (0.41–0.47) | 0.85 (0.82–0.88) | ||||
≥ 4 | 649 (40.1) | 330 (63.6) | 319 (29.0) | 0.64 (0.59–0.68) | 0.71 (0.68–0.74) | 0.51 (0.47–0.55) | 0.80 (0.78–0.83) | ||||
≥ 5 | 204 (12.6) | 145 (27.9) | 59 (5.4) | 0.28 (0.24–0.32) | 0.95 (0.93–0.96) | 0.71 (0.64–0.77) | 0.74 (0.71–0.76) | ||||
Kurstjens et al. | 1472 | 489 | 983 | ||||||||
Cut-off value | > 2 | 1123 (76.3) | 468 (95.7) | 655 (66.6) | 0.96 (0.94–0.98) | 0.33 (0.30–0.36) | 0.40 (0.38–0.43) | 0.94 (0.92–0.97) | |||
> 3 | 1010 (68.6) | 457 (93.5) | 553 (56.3) | 0.93 (0.91–0.95) | 0.44 (0.41–0.47) | 0.44 (0.41–0.47) | 0.93 (0.91–0.95) | ||||
> 4 | 884 (60.1) | 443 (90.6) | 441 (44.9) | 0.90 (0.87–0.93) | 0.55 (0.52–0.58) | 0.49 (0.45–0.52) | 0.92 (0.90–0.94) | ||||
≥ 5 | 756 (51.4) | 423 (86.5) | 333 (33.9) | 0.86 (0.83–0.89) | 0.66 (0.63–0.69) | 0.54 (0.51–0.58) | 0.91 (0.89–0.93) | ||||
≥ 9 | 440 (29.9) | 333 (68.1) | 107 (10.9) | 0.66 (0.62–0.71) | 0.89 (0.87–0.91) | 0.74 (0.70–0.85) | 0.85 (0.83–0.87) | ||||
≥ 10 | 355 (24.1) | 281 (57.5) | 74 (7.5) | 0.56 (0.52–0.60) | 0.92 (0.91–0.94) | 0.78 (0.74–0.82) | 0.82 (0.80–0.84) | ||||
≥ 11 | 275 (18.7) | 229 (46.8) | 46 (4.7) | 0.45 (0.41–0.50) | 0.95 (0.94–0.96) | 0.82 (0.78–0.87) | 0.79 (0.76–0.81) | ||||
≥ 12 | 200 (13.6) | 176 (36.0) | 24 (2.4) | 0.35 (0.30–0.39) | 0.98 (0.97–0.99) | 0.87 (0.82–0.92) | 0.76 (0.74–0.78) | ||||
Aldobyany et al. | 502 | 224 | 278 | ||||||||
Cut-off value | ≥ 3 | 384 (76.5) | 188 (83.9) | 196 (70.5) | 0.81 (0.77–0.84) | 0.28 (0.25–0.30) | 0.35 (0.32–0.37) | 0.75 (0.71–0.80) | |||
≥ 4 | 300 (59.8) | 168 (75.0) | 132 (47.5) | 0.69 (0.65–0.73) | 0.47 (0.44–0.50) | 0.38 (0.35–0.41) | 0.76 (0.73–0.80) | ||||
Nakakubo et al. | 1615 | 519 | 1096 | ||||||||
Cut-off value | > 5 | 762 (47.2) | 397 (76.5) | 365 (33.3) | 0.78 (0.74–0.82) | 0.64 (0.61–0.67) | 0.51 (0.47–0.54) | 0.86 (0.84–0.89) |