| |
qRT-PCR test
|
|---|
|
All
|
Positive
|
Negative
|
Diagnostic test results (Rubin’s rules)
|
|---|
|
Total
|
n (%)
|
Total
|
n (%)
|
Total
|
n (%)
|
Se (CI95%)
|
Sp (95CI%)
|
PPV (95CI%)
|
NPV (95CI%)
|
|---|
|
Vieceli et al.
| |
1475
| |
492
| |
983
| | | | | |
|
Cut-off value
|
≥ 5
| |
847 (57.4)
| |
418 (85.0)
| |
429 (43.6)
|
0.84 (0.80–0.87)
|
0.57 (0.54–0.60)
|
0.48 (0.45–0.51)
|
0.88 (0.86–0.91)
|
|
Tordjman et al.
| |
1618
| |
519
| |
1099
| | | | | |
|
Cut-off value
|
≥ 0
| |
1618 (100.0)
| |
519 (100.0)
| |
1099 (100.0)
|
/
|
/
|
/
|
/
|
| |
≥ 1
| |
1427 (88.2)
| |
503 (96.9)
| |
924 (84.1)
|
0.97 (0.95–0.98)
|
0.16 (0.14–0.18)
|
0.35 (0.33–0.38)
|
0.92 (0.87–0.95)
|
| |
≥ 2
| |
1224 (75.6)
| |
475 (91.5)
| |
749 (68.2)
|
0.92 (0.89–0.94)
|
0.32 (0.29–0.35)
|
0.39 (0.36–0.42)
|
0.89 (0.85–0.92)
|
| |
≥ 3
| |
952 (58.8)
| |
419 (80.7)
| |
533 (48.5)
|
0.81 (0.77–0.84)
|
0.52 (0.49–0.54)
|
0.44 (0.41–0.47)
|
0.85 (0.82–0.88)
|
| |
≥ 4
| |
649 (40.1)
| |
330 (63.6)
| |
319 (29.0)
|
0.64 (0.59–0.68)
|
0.71 (0.68–0.74)
|
0.51 (0.47–0.55)
|
0.80 (0.78–0.83)
|
| |
≥ 5
| |
204 (12.6)
| |
145 (27.9)
| |
59 (5.4)
|
0.28 (0.24–0.32)
|
0.95 (0.93–0.96)
|
0.71 (0.64–0.77)
|
0.74 (0.71–0.76)
|
|
Kurstjens et al.
| |
1472
| |
489
| |
983
| | | | | |
|
Cut-off value
|
> 2
| |
1123 (76.3)
| |
468 (95.7)
| |
655 (66.6)
|
0.96 (0.94–0.98)
|
0.33 (0.30–0.36)
|
0.40 (0.38–0.43)
|
0.94 (0.92–0.97)
|
| |
> 3
| |
1010 (68.6)
| |
457 (93.5)
| |
553 (56.3)
|
0.93 (0.91–0.95)
|
0.44 (0.41–0.47)
|
0.44 (0.41–0.47)
|
0.93 (0.91–0.95)
|
| |
> 4
| |
884 (60.1)
| |
443 (90.6)
| |
441 (44.9)
|
0.90 (0.87–0.93)
|
0.55 (0.52–0.58)
|
0.49 (0.45–0.52)
|
0.92 (0.90–0.94)
|
| |
≥ 5
| |
756 (51.4)
| |
423 (86.5)
| |
333 (33.9)
|
0.86 (0.83–0.89)
|
0.66 (0.63–0.69)
|
0.54 (0.51–0.58)
|
0.91 (0.89–0.93)
|
| |
≥ 9
| |
440 (29.9)
| |
333 (68.1)
| |
107 (10.9)
|
0.66 (0.62–0.71)
|
0.89 (0.87–0.91)
|
0.74 (0.70–0.85)
|
0.85 (0.83–0.87)
|
| |
≥ 10
| |
355 (24.1)
| |
281 (57.5)
| |
74 (7.5)
|
0.56 (0.52–0.60)
|
0.92 (0.91–0.94)
|
0.78 (0.74–0.82)
|
0.82 (0.80–0.84)
|
| |
≥ 11
| |
275 (18.7)
| |
229 (46.8)
| |
46 (4.7)
|
0.45 (0.41–0.50)
|
0.95 (0.94–0.96)
|
0.82 (0.78–0.87)
|
0.79 (0.76–0.81)
|
| |
≥ 12
| |
200 (13.6)
| |
176 (36.0)
| |
24 (2.4)
|
0.35 (0.30–0.39)
|
0.98 (0.97–0.99)
|
0.87 (0.82–0.92)
|
0.76 (0.74–0.78)
|
|
Aldobyany et al.
| |
502
| |
224
| |
278
| | | | | |
|
Cut-off value
|
≥ 3
| |
384 (76.5)
| |
188 (83.9)
| |
196 (70.5)
|
0.81 (0.77–0.84)
|
0.28 (0.25–0.30)
|
0.35 (0.32–0.37)
|
0.75 (0.71–0.80)
|
| |
≥ 4
| |
300 (59.8)
| |
168 (75.0)
| |
132 (47.5)
|
0.69 (0.65–0.73)
|
0.47 (0.44–0.50)
|
0.38 (0.35–0.41)
|
0.76 (0.73–0.80)
|
|
Nakakubo et al.
| |
1615
| |
519
| |
1096
| | | | | |
|
Cut-off value
|
> 5
| |
762 (47.2)
| |
397 (76.5)
| |
365 (33.3)
|
0.78 (0.74–0.82)
|
0.64 (0.61–0.67)
|
0.51 (0.47–0.54)
|
0.86 (0.84–0.89)
|
