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Fig. 3 | BMC Infectious Diseases

Fig. 3

From: Evolution and spread of a highly drug resistant strain of Mycobacterium tuberculosis in Papua New Guinea

Fig. 3

Phylogenetic tree with inferred timeline demonstrating the evolutionary history of 176 MTB (sensu stricto Beijing L2.2.1.1) strains identified in different Papua New Guinea provinces. Phylogeny constructed using the best evolutionary model (Hasegawa–Kishino–Yano substitution, relaxed clock, exponential demographic) revealing two clades (A-Daru dominant clade, B-NCD dominant clade), with tip labels colors; grey—Daru, orange—National Capital District, green—other provinces. Columns show drug resistance associated mutations for first- and second-line drugs (different mutations per column represented by different colors), and putative compensatory mutations in the RNA polymerase genes rpoA and rpoC.; R Rifampicin, H Isoniazid, S Streptomycin, Z Pyrazinamide, E Ethambutol, FQ Fluoroquinolone, AG Aminoglycosides, CP Capreomycin, PAS Para-aminosalicyclic acid, BQ Bedaquiline, Comp_mut Rifampicin compensatory mutations

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