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Table 3 Antibiotic consumption (in DDD per 100 occupied bed days) in general wards and intensive care units pre- and post-intervention

From: Impact of antimicrobial stewardship programs on antibiotic consumption and antimicrobial resistance in four Colombian healthcare institutions

 

Value

General wards

Intensive care units

Coefficient (95% CI)

p

Coefficient (95% CI)

p

CRO

β0

14.44 (12.87 to 16)

< 0.001

22.7 (20.32 to 25.09)

< 0.001

β1

0.39 (0.22 to 0.55)

< 0.001

0.23 (0.06 to 0.4)

0.01

β2

− 2.51 (− 6.05 to 1.03)

0.16

− 11.07 (− 14.02 to − 8.12)

< 0.001

β3

− 0.69 (− 0.93 to − 0.43)

< 0.001

− 0.39 (− 0.6 to − 0.17)

0.001

FEP

β0

18.33 (14.46 to 22.2)

< 0.001

104.06 (88.59 to 119.54)

< 0.001

β1

0.96 (0.55 to 1.37)

< 0.001

1.96 (0.97 to 2.94)

< 0.001

β2

− 5.45 (− 17.42 to 6.51)

0.36

− 73.17 (− 89.77 to − 56.56)

< 0.001

β3

− 1.17 (− 1.99 to − 0.35)

0.006

− 2.06 (− 3.98 to − 1.23)

0.02

TZP

β0

7.36 (5.51 to 9.21)

 < 0.001

31.97 (27.13 to 36.81)

< 0.001

β1

0.56 (0.37 to 0.75)

 < 0.001

0.93 (0.56 to 1.3)

< 0.001

β2

− 3.19 (− 7.64 to 0.21)

0.16

− 26.83 (− 38.59 to − 15.08)

< 0.001

β3

− 0.49 (− 0.77 to − 0.21)

0.001

− 0.93 (− 1.69 to − 0.18)

0.02

ETP

β0

11.67 (8.86 to 14.48)

< 0.001

19.06 (13.84 to 24.29)

< 0.001

β1

0.52 (0.35 to 0.7)

< 0.001

− 0.33 (− 0.61 to − 0.05)

0.02

β2

− 6.25 (− 9.51 to − 2.99)

< 0.001

1.67 (− 2.05 to 5.4)

0.37

β3

− 0.54 (− 0.75 to − 0.32)

< 0.001

0.28 (− 0.02 to 0.57)

0.07

MEM

β0

11.89 (8.77 to 15)

< 0.001

179.82 (162 to 197.65)

< 0.001

β1

1.2 (0.9 to 1.5)

< 0.001

1.8 (0.79 to 2.82)

0.001

β2

− 15.92 (− 23.28 to − 8.57)

< 0.001

− 129.23 (− 144.8 to − 113.66)

< 0.001

β3

− 0.75 (− 1.27 to − 0.23)

0.006

− 1.55 (− 3.01 to − 0.09)

0.04

VAN

β0

6.24 (4.55 to 7.93)

< 0.001

107.73 (95.77 to 119.68)

< 0.001

β1

0.41 (0.27 to 0.55)

< 0.001

0.44 (− 0.47 to 1.35)

0.34

β2

− 2.91 (− 6.14 to 0.33)

0.08

− 65.78 (− 80.56 to − 51)

< 0.001

β3

− 0.53 (− 0.82 to − 0.25)

< 0.001

− 1.09 (− 2.06 to − 0.13)

0.03

  1. β0 baseline consumption, β1 baseline trend, β2 change in consumption after intervention, β3 change in trend after intervention, CI confidence interval, CRO ceftriaxone, ETP ertapenem, FEP cefepime, MEM meropenem; TZP piperacillin/tazobactam, VAN vancomycin
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BMC Infectious Diseases

ISSN: 1471-2334

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