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Table 3 Comparison of diagnostic performance of mNGS and CMTs in immunocompromised patients

From: Diagnostic value of metagenomic next-generation sequencing of bronchoalveolar lavage fluid for the diagnosis of suspected pneumonia in immunocompromised patients

 

CMTs

mNGS

 

Sensitivity%

(95% CI)

Specificity%

(95% CI)

PPV%

(95% CI)

NPV%

(95% CI)

Accuracy%

(95% CI)

Sensitivity%

(95% CI)

Specificity%

(95% CI)

PPV%

(95% CI)

NPV%

(95% CI)

Accuracy%

(95% CI)

Bacterial pneumonia

36 (21–50)

82 (73–90)

53 (31–74)

69 (62–76)

65 (54–76)

80 (63–92)

73 (63–79)

63 (49–72)

87 (75–94)

75 (63–84)

Fungal pneumonia

50 (37–62)

63 (50–75)

57 (42–71)

54 (45–67)

57 (44–69)

91 (79–98)

66 (54–72)

72 (63–77)

89 (73–97)

78 (66–85)

Pneumocystis jiroveciia

28 (16–28)

100 (91–100)

100 (58–100)

71 (66–71)

74 (66–74)

100 (86–100)

86 (79–86)

81 (70–81)

100 (90–100)

91 (82–91)

Pneumocystis jiroveciib

88 (72–97)

84 (75–89)

76 (62–83)

93 (83–98)

86 (74–92)

100 (86–100)

86 (79–86)

81 (70–81)

100 (90–100)

91 (82–91)

Aspergillus spp.

86 (63–99)

97 (92–98)

75 (41–87)

98 (94–100)

96 (88–98)

57 (23–71)

98 (95–100)

80 (33–99)

95 (92–97)

94 (87–97)

Viral pneumonia

53 (34–53)

100 (95–100)

100 (64–100)

89 (84–89)

90 (81–90)

93 (70–100)

83 (77–85)

61 (46–65)

98 (90–100)

86 (75–88)

  1. mNGS metagenomic next-generation sequencing, CMTs conventional microbiological tests, PPV positive predictive value, NPV negative predictive value
  2. aDetect by Gomori methenamine silver staining only
  3. bDetect by a combination of Gomori methenamine silver staining and serum (1,3)-b-D-glucan (≥ 80 ng/l was defined as positive)