Table 1 Clinical and demographic characteristics of the study population according to TB treatment intermittency frequency in the continuation phase
| Â | N | 2-3x/wk | 5-7x/wk | Combined | P-value |
|---|---|---|---|---|---|
|  |  | N = 300 | N = 2003 | N = 2303 |  |
Age at TB diagnosis—median (IQR) | 2303 | 34.80 (28.95, 42.61) | 36.61 (29.97, 44.82) | 36.41 (29.72, 44.38) | 0.021 |
Male sex | 2303 | 84% (251) | 55% (1107) | 59% (1358) |  < 0.001 |
CD4 at TB diagnosis—median (IQR) | 1602 | 97 (43, 196) | 173 (67, 310) | 156.5 (60.0, 295) |  < 0.001 |
Missing baseline CD4 indicator | 2303 |  |  |  |  < 0.001 |
 Not missing |  | 91% (273) | 66% (1329) | 70% (1602) |  |
 Missing |  | 9% (27) | 34% (674) | 30% (701) |  |
Baseline HIV-1 RNA (log10-transformed) | 438 | 5.15 (4.70, 5.64) | 5.10 (4.55, 5.60) | 5.11 (4.63, 5.62) | 0.609 |
Missing baseline HIV-1 RNA indicator | 2303 |  |  |  |  < 0.001 |
 Not missing |  | 58% (175) | 13% (263) | 19% (438) |  |
 Missing |  | 42% (125) | 87% (1740) | 81% (1865) |  |
Site of TB | 2303 |  |  |  |  < 0.001 |
 Pulmonary only |  | 54% (163) | 78% (1556) | 75% (1719) |  |
 Any extrapulmonary |  | 45% (135) | 22% (443) | 25% (578) |  |
 Unknown |  | 1% (2) | 0% (4) | 0% (6) |  |
CCASAnet site | 2303 |  |  |  |  < 0.001 |
 Brazil |  | 0% (0) | 12% (245) | 11% (245) |  |
 Chile |  | 12% (35) | 0% (0) | 2% (35) |  |
 Haiti |  | 0% (0) | 78% (1560) | 68% (1560) |  |
 Honduras |  | 1% (2) | 1% (21) | 1% (23) |  |
 Mexico |  | 8% (25) | 0% (2) | 1% (27) |  |
 Peru |  | 79% (238) | 9% (175) | 18% (413) |  |
TB relative to ART | 2303 | Â | Â | Â | 0.047 |
 Not on ART at TB diagnosis |  | 65% (196) | 59% (1188) | 60% (1384) |  |
 On ART at TB diagnosis |  | 35% (104) | 41% (815) | 40% (919) |  |
Days on ART at TB diagnosis | 919 | 131.5 (28.5, 401.5) | 108 (3, 566.5) | 113 (8, 543) | 0.272 |
Days to ART after TB diagnosis | 1384 | 46 (26.00, 79.25) | 28 (14, 63) | 30 (14, 67) |  < 0.001 |
Days on TB treatment | 2303 | 245 (180, 298) | 194 (182, 224) | 195 (182, 236) |  < 0.001 |
Days from ART initiation post-TB dx to TB continuation stop | 1384 | 184 (130.8, 251) | 168 (131, 190) | 168 (131, 197) |  < 0.001 |
Missing Initiation phase stop date | 2303 |  |  |  |  < 0.001 |
 Non-missing |  | 92% (275) | 100% (1999) | 99% (2274) |  |
 Missing |  | 8% (25) | 0% (4) | 1% (29) |  |
Missing Continuation phase stop date | 2303 |  |  |  |  < 0.001 |
 Non-missing |  | 87% (260) | 97% (1946) | 96% (2206) |  |
 Missing |  | 13% (40) | 3% (57) | 4% (97) |  |
Died | 2303 |  |  |  |  < 0.001 |
 No |  | 79% (238) | 89% (1783) | 88% (2021) |  |
 Yes |  | 21% (62) | 11% (220) | 12% (282) |  |
Follow-up time (yrs) | 2303 | 6.55 (3.79, 8.89) | 3.61 (1.17, 6.49) | 4.03 (1.33, 7.13) |  < 0.001 |