Skip to main content

Table 3 SIMEX estimates for the mixed-effects model of log10 LAM concentration and log10 CFU concentration

From: Sputum lipoarabinomannan (LAM) as a biomarker to determine sputum mycobacterial load: exploratory and model-based analyses of integrated data from four cohorts

Type

Intercept

log10 LAM Slope (Centered at Median)

Shift for Intercept Day 7 and Day 13

IIV Intercept (Variance)

Residual Variability

Observed (Estimated Mixed Effect Parameter)

5.986

0.763

 − 0.806

0.271

0.480

SIMEX Simulation

6.038

0.795

 − 0.788

0.264

0.465

Ratio (Observed/ SIMEX)

0.991

0.960

1.022

1.026

1.031

  1. CFU, colony-forming units; IIV, interindividual variability; LAM, lipoarabinomannan; log10, 10 logarithm; SIMEX, simulation-extrapolation