Table 3 Risk factors for occurrence of IFD
Variables | IFD (n = 22) | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|---|
χ2 | P value | P value | HR (95%CI) | ||
Recipient age | 0.086 | 0.130 | 1.067 (1.014–1.122) | ||
Recipient sex | 0.604 | 0.437 | |||
Male | 14 (63.6%) | ||||
Female | 8 (36.4%) | ||||
Underling disease | 0.606 | 0.962 | |||
AA | 2 (9.1%) | ||||
ALL | 7 (31.8%) | ||||
AML | 10 (45.5%) | ||||
MDS | 2 (9.1%) | ||||
Others | 1 (4.5%) | ||||
Donor age | 0.6828 | ||||
> 36 | 13 (54.2%) | ||||
≤ 36 | 11 (45.8%) | ||||
Donor sex | 0.491 | 0.483 | |||
Male | 18 (81.8%) | ||||
Female | 4 (18.2%) | ||||
Blood type | 1.747 | 0.417 | |||
Match | 11 (50.0%) | ||||
Major mismatch | 7 (31.8%) | ||||
Minor mismatch | 4 (18.2%) | ||||
Neutrophil enengraftment | 21 (95.5%) | 2.292 | 0.130 | ||
Platelet engraftment | 19 (86.4%) | 2.131 | 0.144 | ||
aGVHD | 21 (95.4%) | ||||
I–II | 16 (72.7%) | 8.875 | 0.012 | 0.181 | 17.896 (2.145–49.361) |
III–IV | 5 (22.7%) | 10.422 | 0.005 | 0.017 | 13.987 (1.132–62.999) |
cGVHD | 3 (13.6%) | 1.686 | 0.430 | ||
CMV | 20 (90.9%) | 6.962 | 0.008 | 0.007 | 35.97 (2.630–492.01) |
Epstein–Barr virus | 5 (22.7%) | 1.128 | 0.298 | ||
Recipient rs1554013 | 3.030 | 0.082 | 0.614 | 0.352 (0.078–1.589) | |
Recipient rs2243283 | 4.659 | 0.031 | 0.066 | 3.303 (0.924–11.809) | |
Recipient rs419598 | 3.080 | 0.079 | 0.088 | 4.133 (0.630–27.104) | |
Recipient rs4804800 | 3.522 | 0.061 | 0.073 | 5.898 (0.847–41.068) | |
Recipient rs2305619 | 4.520 | 0.034 | 0.006 | 10.249 (1.982–53.004) | |
Recipient rs7248637 | 4.159 | 0.041 | 0.749 | 1.933 (0.010–366.116) | |
Donor rs7309123 | 4.349 | 0.037 | 0.069 | 1.066 (0.256–4.449) | |
Donor rs419598 | 7.934 | 0.005 | 0.084 | 3.545 (0.900–13.965) | |
Donor rs3921 | 5.830 | 0.016 | 0.995 | 3.646 (0–1467) | |
Donor rs4257674 | 5.238 | 0.022 | 0.965 | 0.045 (0–1806) | |
Donor rs2305619 | 2.719 | 0.099 | 0.046 | 1.384 (0.351–5.466) | |