Table 2 Case of F. nucleatum infection
From: A case report of severe Fusobacterium nucleatum sepsis secondary to nephrectomy
Case/patient | Age range (year) | Sex | Background | Presentation | Source | Thrombosis | Treatment | Susceptibility | Treatment duration | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
1 | 40–50 | Male | Rectal cancer | Fever, lower abdominal pain | Bowel perforation with intra-abdominal abscess | None | Drainage + meropenem + vancomycin then amoxicillin/clavulanate | Meropenem (S) Amoxicillin/clavulanate (N/T) but penicillin (S) | 28 days | Survived |
2 | 90–100 | Female | AF, HTN | Fever, lethargy | Mass in the posterior oral cavity (biopsy: squamous cell carcinoma), liver abscess | None | Piperacillin/tazobactam | S | 1 day | Died |
3 | 40–50 | Male | Sickle cell anemia | No fever, lower limb pain | Unknown | Deep vein thrombosis | Anti-coagulation | N/T | NA | Survived |
4 | 20–30 | Male | Developmental delay, deafness, seizure disorder | Fever, cough, shortness of breath, vomiting | Liver abscess | None | Vancomycin + ceftriaxone then piperacillin/tazobactam + metronidazole + drainage | NA |  > 6 weeks | Survived |
5 | 20–30 | Male | Sickle cell anemia | Fever, flank pain | Unknown | Left renal vein thrombosis | Anti-coagulation + metronidazole then amoxicillin/clavulanate | Metronidazole(N/T) Amoxicillin/clavulanate(N/T) but meropenem(S) and penicillin(S) | 28 days | Survived |
6 | 20–30 | Male | None | Fever, right upper quadrant abdominal pain | Liver abscess | None | Vancomycin + piperacillin/tazobactam + drainage then ertapenem | NA |  > 10 weeks | Survived |
7 | 70–80 | Female | Ovarian cancer, HTN, CAD | No fever, cough | Lower respiratory tract | None | Meropenem + moxifloxacin | Meropenem(S) Moxifloxacin(N/T) | 14 days | Died |
8 | 70–80 | Male | HTN, DM, CAD | Fever, dull, epigastric abdominal pain | Unknown | Hepatic vein thrombosis | Cefepime then anti-coagulation + clindamycin | Clindamycin(S) Cefepime(N/T) but cefoxitin(S) |  > 14 days | Survived |
9 | 40–50 | Male | Chronic pancreatitis and pancreatic pseudocyst | Fever, myalgias | Liver abscess | Hepatic vein thrombosis | Ceftriaxone + ofloxacin then amoxicillin/clavulanate + metronidazole + anti-coagulation + drainage | Ceftriaxone(N/T) Ofloxacin(N/T) Amoxicillin/clavulanate(S) Metronidazole(S) | 10 months | Survived |
10 | 20–30 | Male | None | Fever, sore throat, right neck pain and chest pain | Acute tonsillitis, pyothorax | Right internal jugular vein thrombophlebitis | Ampicillin/sulbactam then penicillin G then clindamycin then amoxicillin/clavulanate | NA | 6 weeks | Survived |
11 | 40–50 | Male | Dementia, epilepsy | Fever, pain over right hip | Hip abscess | None | Ampicillin/sulbactam + Fosfomycin + metronidazole + surgery then amoxicillin/clavulanate + metronidazole | Metronidazole(S) Ampicillin/sulbactam(N/T) Amoxicillin/clavulanate(N/T) but penicillin(S) | 6 weeks | Survived |
12 | 10–20 | Male | Gonorrhea | Fever, sore throat, cough and chest pain | Tonsillitis, pneumonia | Right internal jugular vein thrombophlebitis | Levofloxacin then ampicillin-sulbactam then ampicillin then metronidazole | NA |  > 7 days Discharged with 4 weeks' metronidazole | Unknown (lost) |
13 | 60–70 | Female | Ovarian cancer | Fever, abdominal pain | Intra-abdominal | None | NA | NA | 2 days | Died |