Table 1 Characteristics of participants

Participants (total = 8375)

74.1% (6131/8269)

25.9% (2138/8269)

 < .01

Age

 18–30

14.0% (859)

11.1% (237)

 < .01

 31–40

21.4% (1314)

23.5% (503)

.05

 41–50

24.4% (1495)

25.7% (549)

ns

 51–60

31.1% (1908)

28.4% (607)

.02

 > 61

7.2% (440)

8.7% (187)

.02

 Missing or invalid data

1.9% (115)

2.6% (55)

ns

 Recovered after COVID-19

1.8% (110)

1.4% (28)

ns

1st vaccine (total = 8269)

 BNT162b2

59.1% (3623)

64.3% (1375)

 < .01

 ChAdOx 2

34.4% (2108)

30.0% (641)

 < .01

 mRNA-1273

3.3% (203)

2.9% (63)

ns

 Missing or invalid data

3.2% (197)

2.8% (59)

ns

2nd vaccine (total = 8246)

 BNT162b2a

69.2% (4,244)

69.2% (1,479)

ns

 ChAdOx

9.2% (564)

9.3% (198)

ns

 mRNA-1273

6.1% (371)

6.0% (129)

ns

 Missing or invalid data

15.2% (931)

15.4% (330)

ns

 No 2nd vaccination

0.3% (21)

0.1% (2)

ns

Vaccine combination, if > 1 vaccination (total = 8246)

 BNT162b2 + BNT162b2

49.5% (3024)

54.1% (1155)

 < .01

 mRNA-1273 + mRNA-1273

2.6% (158)

2.3% (49)

ns

 ChAdOx + ChAdOx

9.1% (554)

9.1% (194)

ns

 ChAdOx + BNT162b2

19.0% (1161)

14.2% (304)

 < .01

 ChAdOx + mRNA-1273

3.4% (206)

3.7% (78)

ns

 Missing information on 1st or 2nd vaccine

16.5% (1007)

16.7% (356)

ns

Time of day of vaccination

Based on 13,876 vaccinations with information on time of day and gender

 Morning

68.9% (7148)

68.3% (2389)

ns

 Afternoon

31.1% (3230)

31.7% (1109)

ns

Reactions (multiple answers were possible)

Based on 16,207 vaccinations with information on reactions and gender

 None

23.1% (2765)

32.2% (1358)

 < .01

1.59 (1.47–1.72)

 Headache (very strong / strong)

17.7% (2122)

10.1% (425)

 < .01

0.52 (0.47–0.58)

 Pain at the injection site

52.2% (6257)

44.8% (1887)

 < .01

0.74 (0.69–0.80)

 Chills

21.7% (2606)

16.1% (677)

 < .01

0.69 (0.63–0.76)

 Fever

17.9% (2143)

13.9% (585)

 < .01

0.74 (0.67–0.82)

 General feeling of malaise

31.4% (3765)

26.5% (1115)

 < .01

0.79 (0.73–0.85)

 Unusual fatigue

31.4% (3762)

25.3% (1066)

 < .01

0.74 (0.68–0.80)

 Rash

2.5% (295)

0.7% (28)

 < .01

0.27 (0.18–0.39)

 Gastrointestinal complaints

5.6% (670)

2.5% (104)

 < .01

0.43 (0.35–0.53)

 Sweats

9.7% (1169)

7.5% (315)

 < .01

0.75 (0.66–0.85)

 Vertigo

10.2% (1220)

5.7% (242)

 < .01

0.54 (0.47–0.62)

 Muscle or joint pain

28.4% (3412)

22.8% (960)

 < .01

0.74 (0.68–0.81)

 Other

0.8% (814)

3.7% (155)

 < .01

0.52 (0.44–0.63)

 Anaphylactic reaction

0.3% (31)

0.2% (8)

ns

0.73 (0.34–1.60)

Incapacity to work

Based on 13,795 vaccinations with information on incapacity to work and gender

 None

75.3% (7746)

81.9% (2869)

 < .01

 1–2 days

18.7% (1924)

14.3% (501)

 < .01

 3 or more days

6.0% (622)

3.8% (133)

 < .01