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Table 2 Incidence rates of AOM and 95% confidence intervals by PCV period among commercially insured children aged < 18 years, in episodes per 1000 patient-years (1998–2018)

From: Incidence of acute otitis media in children in the United States before and after the introduction of 7- and 13-valent pneumococcal conjugate vaccines during 1998–2018

 

All agesa

Ages < 2

Periodb

Overall

Simple

Recurrentc

Overall

Simple

Recurrent

Pre-PCV7

263.2 (262.4; 264.0)

209.3 (208.3; 210.3)

65.4 (64.8; 66.0)

1170.2 (1164.3; 1176.2)

801.3 (794.5; 808.3)

426.6 (421.6; 431.6)

Early PCV7

209.4 (209.2; 209.7)

172.7 (172.5; 172.9)

36.7 (36.6; 36.8)

880.6 (879.1; 882.0)

647.9 (646.7; 649.2)

232.6 (231.9; 233.4)

Late PCV7

212.8 (212.6; 212.9)

175.8 (175.7; 176.0)

36.9 (36.9; 37.0)

854.9 (853.8; 856.0)

626.9 (626.0; 627.8)

228.0 (227.4; 228.6)

Early PCV13

210.0 (209.9; 210.2)

175.5 (175.4; 175.7)

34.5 (34.4; 34.6)

813.1 (812.0; 814.1)

602.5 (601.6; 603.5)

210.5 (210.0; 211.1)

Late PCV13

198.1 (197.9; 198.2)

165.1 (164.9; 165.2)

33.0 (33.0; 33.1)

768.8 (767.7; 769.8)

562.6 (561.8; 563.5)

206.1 (205.6; 206.7)

 

Ages 2–4

Ages 5–17

Period

Overall

Simple

Recurrent

Overall

Simple

Recurrent

Pre-PCV7

547.4 (544.2; 550.6)

433.0 (429.0; 436.9)

144.3 (142.0; 146.6)

115.6 (114.9; 116.2)

106.4 (105.5; 107.2)

12.7 (12.4; 13.0)

Early PCV7

427.8 (427.0; 428.6)

350.3 (349.5; 351.0)

77.5 (77.2; 77.8)

91.2 (91.0; 91.4)

84.6 (84.5; 84.8)

6.6 (6.5; 6.6)

Late PCV7

432.9 (432.3; 433.5)

354.9 (354.4; 355.5)

77.9 (77.7; 78.2)

93.9 (93.8; 94.1)

87.6 (87.5; 87.7)

6.4 (6.3; 6.4)

Early PCV13

430.0 (429.4; 430.6)

355.1 (354.5; 355.6)

75.0 (74.7; 75.2)

99.0 (98.8; 99.1)

92.3 (92.2; 92.5)

6.6 (6.6; 6.7)

Late PCV13

410.3 (409.7; 410.9)

338.4 (337.9; 339.0)

71.9 (71.6; 72.1)

91.8 (91.7; 91.9)

86.2 (86.1; 86.3)

5.6 (5.5; 5.6)

  1. AOM acute otitis media, PY person-years
  2. aConfidence intervals were calculated using the Pearson method
  3. bTime periods are defined as follows: Pre-PCV7: 1998–1999; Early PCV7: 2001–2005; Late PCV7: 2006–2009; Early PCV13: 2011–2013; Late PCV13: 2014–2018. Years 2000 and 2010 are considered transition years and were excluded
  4. cRecurrent AOM was defined as having three or more episodes within a 6 months period or 4 or more episodes within a 12 month period, with at least one episode in the preceding 6 months