Fig. 2

Rates of severe (ISR) and critical (ICR) obtained with an indirect method based on a ratio of ratios. A The colored points represent the reported mortality rates of hospitalized (top) and ICU SARS-Cov-2 patients, each study is reported in a different color. The black line shows the estimated outcome rates for each age obtained from our hierarchical Bayesian logistic regression, and the shaded regions show the 95% credibility intervals. 68 data points from 8 reports were used for hospital mortality, and 43 data points from 8 reports were included for ICU mortality. B The colored points show the estimated rates of severe (left) and critical (center) disease, obtained by dividing the age-stratified IFRs of the three relevant meta-analyses [1,2,3] by the corresponding values obtained in A. The points show the mean values of the posterior distribution, and bars show 95% credibility intervals (we omit these for Brazeau et al. since the credibility intervals around the mean estimates are not reported). The rightmost plot shows the IFRs reported by each of the studies. The black line and shaded region in each panel show the meta-analysis estimates we obtained with the direct method (Fig. 1)