|
Variable/Category
|
Univariate analysis
|
Multivariable analysis
|
|---|
|
HR (95% CI)
|
P value
|
HR (95% CI)
|
P value
|
|---|
|
MP dose
| |
< 0.0001
| |
< 0.0001
|
|
LD MP vs NMP
|
0.35 (0.22,0.56)
|
< 0.0001
|
0.37 (0.23,0.59)
|
< 0.0001
|
|
HD MP vs NMP
|
0.55 (0.34,0.88)
|
0.0132
|
0.56 (0.35,0.91)
|
0.0183
|
|
HD MP vs LD MP
|
1.56 (0.94,2.57)
|
0.0855
|
1.53 (0.91, 2.56)
|
0.1076
|
|
Diabetes
|
1.05 (0.72,1.51)
|
0.8124
| | |
|
Hypertension
|
2.03 (1.36,3.05)
|
0.0006
| | |
|
Chronic kidney disease
|
1.66 (1.01,2.73)
|
0.0468
| | |
|
Male vs female
|
1.38 (0.94,2.03)
|
0.1050
| | |
|
Respiratory rate > 22 bpm
|
1.66 (1.07,2.57)
|
0.0232
| | |
|
Older age ≥ 60 years
|
2.22 (1.31,3.75)
|
0.0030
| | |
|
Obesity status BMI ≥ 30 kg/m2
|
1.05 (0.73,1.51)
|
0.8053
| | |
|
Cancer
|
1.90 (1.24,2.92)
|
0.0032
|
1.68 (1.03,2.69)
|
0.0376
|
|
CRP > 20 mg/L
|
0.77 (0.45,1.33)
|
0.3500
| | |
|
Ferritin ≥ 1400 μg/L
|
1.11 (0.74,1.67)
|
0.6028
| | |
|
Supplemental oxygen
| |
0.0593
| | |
|
NMV vs none
|
1.33 (0.72,2.47)
|
0.3661
| | |
|
MV vs none
|
1.72 (1.09,2.71)
|
0.0194
| | |
|
qSOFA
| |
< 0.0001
| |
< 0.0001
ara>
|
|
qSOFA rec 1 vs 0
|
2.28 (1.53,3.38)
|
< 0.0001
|
1.81 (1.09,2.98)
|
0.0213
|
|
qSOFA rec 2 vs 0
|
6.83 (4.13,11.28)
|
< 0.0001
|
5.16 (3.07,8.66)
|
< 0.0001
|
|
qSOFA rec 3 vs 0
|
8.21 (5.64,11.95)
|
< 0.0001
|
11.81 (6.46,21.57)
|
< 0.0001
|
|
Creatinine ≥ 1.5 mg/dL
|
2.02 (1.39,2.94)
|
0.0002
|
2.16 (1.39,3.34)
|
0.0006
|
- Risk of in-hospital mortality by Cox regression model. Any P < 0.05 was statistically significant
- MV mechanical ventilation; NMV non mechanical ventilation; HR hazard ratio; CI confidence interval
