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Table 2 Factors associated with survival in patients with AIDS followed for up to 10 years after diagnosis, São Paulo State, 2003 to 2014

From: Mortality and survival of tuberculosis coinfected patients living with AIDS in São Paulo, Brazil: a 12-year cohort study

Characteristics Total (n = 35,515) Dead (n = 8,486) Alive (n = 27,029) HRunadjusted (95% CI) HRadjusted (95% CI)
N (%) N (%) N (%)
Sex
 Female 13,148 (100.0) 2686 (20.4) 10,462 (79.6) 1 1
 Male 22,367 (100.0) 5800 (25.9) 16,567 (74.1) 1.37 (1.31–1.45) 1.26 (1.14–1.39)
Age group (years)
 13 to 29 8202 (100.0) 1584 (19.3) 6618 (80.7) 1 1
 30 to 49 22,963 (100.0) 5564 (24.2) 17,399 (75.8) 1.36 (1.28–1.45) 1.14 (1.04–1.26)
 ≥ 50 4350 (100.0) 1338 (30.8) 3012 (69.2) 1.94 (1.79–2.11) 1.35 (1.18–1.54)
Year of AIDS diagnosis
 2007 6178 (100.0) 1202 (19.5) 4976 (80.5) 1 1
 2006 6506 (100.0) 1394 (21.4) 5112 (78.6) 1.01 (1.01–1.10) 1.02 (1.01–1.02)
 2005 7097 (100.0) 1710 (24.1) 5387 (75.9) 1.06 (1.01–1.18) 1.03 (1.03–1.04)
 2004 7220 (100.0) 1846 (25.6) 5374 (74.4) 1.09 (1.01–1.18) 1.05 (1.04–1.06)
 2003 8514 (100.0) 2334 (27.4) 6180 (72.6) 1.13 (1.04–1.22) 1.10 (1.05–1.12)
Region*
 GSPRa 5586 (100.0) 1252 (22.4) 4334 (77.6) 1 1
 SPC 12,880 (100.0) 2994 (23.2) 9886 (76.8) 1.05 (1.02–1.12) 1.16 (1.01–1.32)
 ISPS 14,958 (100.0) 3752 (25.1) 11,206 (74.9) 1.14 (1.04–1.16) 1.43 (1.25–1.62)
 SPCA 2085 (100.0) 487 (23.4) 1598 (76.6) 1.33 (1.09–1.42) 1.49 (1.21–1.82)
Education (years of schooling)
 ≥ 12 3065 (100.0) 432 (14.1) 2633 (85.9) 1 1
 8 to 11 10,643 (100.0) 1980 (18.6) 8663 (81.4) 1.36 (1.22–1.51) 1.64 (1.35–1.99)
 4 to 7 11,065 (100.0) 2929 (26.5) 8136 (73.5) 2.02 (1.82–2.23) 2.35 (1.93–2.86)
 1 to 3 3513 (100.0) 1086 (30.9) 2427 (69.1) 2.38 (2.02–2.81) 2.41 (1.77–3.30)
 Illiterate 683 (100.0) 209 (30.6) 474 (69.4) 2.42 (2.17–2.71) 2.61 (2.11–3.24)
Race
 White 19,412 (100.0) 4538 (23.4) 14,874 (76.6) 1 1
 Mixed race/black 7428 (100.0) 1706 (23.0) 5722 (77.0) 1.29 (1.19–1.40) 1.07 (1.02–1.18)
 Black 3125 (100.0) 916 (29.3) 2209 (70.7) 2.11 (1.22–3.64) 1.27 (1.12–1.45)
 Yellow 147 (100.0) 38 (25.9) 109 (74.1) 1.27 (0.90–1.80) 0.47 (0.17–1.25)
 Indigenous 40 (100.0) 14 (35.0) 26 (65.0) 0.96 (0.90–1.02) 1.67 (0.54–5.21)
Exposure category
 MSM 7160 (100.0) 1203 (16.8) 5957 (83.2) 1 1
 Heterosexual 20,978 (100.0) 4427 (21.1) 16,551 (78.9) 1.30 (1.21–1.39) 1.16 (1.03–1.31)
 IDU 3539 (100.0) 1203 (34.0) 2336 (66.0) 2.35 (2.15–2.58) 1.73 (1.49–2.02)
TB–HIV co-infection
 No 30,934 (100.0) 6712 (21.7) 24,222 (78.3) 1 1
 Yes 4581 (100.0) 1774 (38.7) 2807 (61.3) 2.05 (1.94–2.16) 1.70 (1.49–1.87)
ARV regimenb
 HAART2 1226 (100.0) 82 (6.7) 1144 (93.3) 1 1
HAART1 24,188 (100.0) 2593 (10.7) 21,595 (89.3) 1.71 (1.37–2.13) 1.94 (1.47–2.55)
 Pre-HAART 28 (100.0) 5 (17.9) 23 (82.1) 3.07 (1.25–7.58) 5.35 (4.03–7.10)
 No ARV 10,073 (100.0) 5806 (57.6) 4267 (42.4) 17.6 (14.2–21.9) 8.22 (2.95–22.87)
CD4 (cells/mm3)
 ≥ 500 3896 (100.0) 294 (7.5) 3602 (92.5) 1 1
 350–499 3533 (100.0) 331 (9.4) 3202 (90.6) 1.26 (1.05–1.50) 1.31 (1.07–1.60)
 200–349 11,198 (100.0) 1263 (11.3) 9935 (88.7) 1.65 (1.43–1.89) 1.47 (1.25–1.74)
 < 200 11,228 (100.0) 2000 (17.8) 9228 (82.2) 2.78 (2.43–3.18) 2.31 (1.97–2.72)
Viral load
 40–500 3978 (100.0) 327 (8.2) 3651 (91.8) 1 1
 > 500 23,381 (100.0) 3281 (14.0) 20,100 (86.0) 1.91 (1.68–2.17) 1.99 (1.72–2.30)
  1. Cox proportional hazards model
  2. Observation: The difference between n and the total number of the categories of each variable corresponds to the number of missing information
  3. MSM: Men who have sex with men; IDU: Injection drug user; HR: hazard ratio; 95% CI: 95% confidence interval; MSM: men having sex with men; IDU: injection drug user; ARV: antiretroviral therapy; Pre-HAART: nucleoside reverse transcriptase inhibitors; HAART1: non-nucleoside reverse transcriptase inhibitors/protease inhibitors; HAART2: regimens containing at least one third-line ARV; SPC: São Paulo City (Capital); GSPR: Greater São Paulo Region, excluding the capital; SPCA: São Paulo State Coastal Area; ISSP: Interior São Paulo State
  4. aExcluding São Paulo City
  5. bThe more complex regimen was used