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Table 2 Bacteremia prediction capability indicated with AUCsa of biomarkers (CRP/PCT) and models (random forest/logistic regression)

From: Bacteremia detection from complete blood count and differential leukocyte count with machine learning: complementary and competitive with C-reactive protein and procalcitonin tests

Methods/Group

CBC/DCb

CRP&CBC/DCc

PCT&CBC/DCd

Cross-validation

Testing

 

Cross-validation

Testing

 

Cross-validation

Testing

Used biomarker

–

–

CRP

0.692 ± 0.017

0.699

PCT

0.748 ± 0.021

0.731

MLe models

        

 Random forest

0.792 ± 0.010

0.802

CRP excludedf

0.797 ± 0.010

0.806

PCT excludedh

0.759 ± 0.022

0.767

   

Includedg

0.806 ± 0.011

0.814

Included

0.777 ± 0.018

0.767

 Logistic regression

0.763 ± 0.009

0.772

Excluded

0.769 ± 0.009

0.775

Excluded

0.735 ± 0.030

0.734

   

Included

0.784 ± 0.011

0.790

Included

0.761 ± 0.024

0.745

  1. aAreas under the ROC curve
  2. bComplete blood count/differential leukocyte count
  3. cC-reactive protein and complete blood count/differential leukocyte count
  4. dProcalcitonin and complete blood count/differential leukocyte count
  5. eMachine learning
  6. fTrained and validated based on CBC/DC data of CRP&CBC/DC group (n = 253,009)
  7. gTrained and validated based on CBC/DC and CRP data of CRP&CBC/DC group
  8. hTrained and validated based on CBC/DC data of PCT&CBC/DC group (n = 17,033)