Whole blood GBP5 protein levels in patients with and without active tuberculosis

BMC Infectious Diseases

Table 2 The comparison of reactivity between GBP5 and IGRA in different clinical groups

	n	GBP5+	IGRA+	P value
Active TB	232	181 (78.02%)	180 (77.59%)	>0.999
PTB	204	158 (77.45%)	160 (78.43%)	0.905
EPTB	28	23 (82.14%)	20 (71.43%)	0.528
non–TB	238	79 (33.19%)	56 (23.53%)	0.025
NTM	11	8 (72.73%)	2 (18.18%)	0.030
OLD*	227	71 (31.28%)	54 (23.79%)	0.093

The sensitivity, specificity, positive predictive value, and negative predictive value of the GBP5 assay were 78.02, 66.81, 69.61 and 75.71%, respectively, and those of IGRA were 77.59, 76.47%, 76.27 and 77.78%
GBP5+ Individual with positive GBP5 result, IGRA+ Individual with positive interferon gamma release assay result, Active TB active tuberculosis, PTB pulmonary tuberculosis, EPTB extrapulmonary tuberculosis, non-TB non-tuberculosis other lung diseases, NTM non-tuberculosis mycobacterium, OLD other lung disease
*Including fungal pneumonia (n = 7), mycoplasma pneumonia (n = 3), bacterial pneumonia (n = 173), lung cancer (n = 16) and non-infection non-cancer lung disease (n = 28)

ISSN: 1471-2334