Table 3 Performance of 6 coding algorithms using ICD-10-CM codes for years 2016–2019 to identify people with hepatitis C virus infection according to 3 reference standards (RSs) and 2 study periods

Positive predictive value

1. ≥ 1OP codes

37.3

55.6

94.4

66.7

82.1

94.8

(95% CI)

(32.1–42.6)

(50.1–61.0)

(92.0–96.9)

(61.5–71.8)

(77.9–86.3)

(92.3–97.2)

2. ≥ 2 OP codes

38.9

59.0

96.2

67.6

84.3

96.6

(95% CI)

(33.3–44.5)

(53.4–64.7)

(94.1–98.4)

(62.2–72.9)

(80.1–88.5)

(94.5–98.7)

3. ≥ 3 OP codes

40.2

62.0

97.8

69.7

87.5

97.8

(95% CI)

(34.4–46.1)

(56.2–67.8)

(96.0–99.5)

(64.3–75.2)

(83.5–91.4)

(96.0–99.5)

4. ≥ 2OP or ≥ 1IP codes

37.7

55.2

93.8

65.9

80.7

96.1

(95% CI)

(32.5–42.9)

(49.9–60.5)

(91.2–96.4)

(60.8–70.9)

(76.5–84.9)

(94.1–98.2)

5. ≥ 3OP or ≥ 1IP codes

38.5

57.1

95.0

67.5

83.0

97.2

(95% CI)

(33.1–43.8)

(51.7–62.6)

(92.5–97.4)

(62.4–72.7)

(78.8–87.1)

(95.3–99.0)

6. ≥ 4OP or ≥ 1IP codes

39.0

58.4

95.4

67.9

83.6

97.7

(95% CI)

(33.5–44.5)

(52.8–63.9)

(93.1–97.8)

(62.6–73.1)

(79.5–87.8)

(96.0–99.4)

Sensitivity

1. ≥ 1OP codes

73.3

80.4

75.2

63.3

67.7

58.5

(95% CI)

(66.6–80.1)

(75.2–85.6)

(71.0–79.4)

(58.2–68.5)

(63.1–72.3)

(54.3–62.7)

2. ≥ 2 OP codes

69.1

77.2

69.3

58.1

62.8

53.9

(95% CI)

(62.0–76.1)

(71.7–82.7)

(64.8–73.8)

(52.8–63.3)

(58.1–67.6)

(49.6–58.2)

3. ≥ 3 OP codes

66.1

75.0

65.1

55.4

60.3

50.5

(95% CI)

(58.8–73.3)

(69.3–80.7)

(60.5–69.7)

(50.2–60.7)

(55.5–65.1)

(46.2–54.8)

4. ≥ 2OP or ≥ 1IP codes

77.0

83.0

77.6

65.1

69.2

61.7

(95% CI)

(70.6–83.4)

(78.1–88.0)

(73.6–81.7)

(60.0–70.2)

(64.7–73.8)

(57.6–65.9)

5. ≥ 3OP or ≥ 1IP codes

73.9

80.8

74.0

62.8

66.9

58.7

(95% CI)

(67.2–80.6)

(75.7–86.0)

(69.7–78.2)

(57.6–67.9)

(62.3–71.6)

(54.5–62.9)

6. ≥ 4OP or ≥ 1IP codes

72.1

79.5

71.5

60.7

64.9

56.8

(95% CI)

(65.3–79.0)

(74.2–84.8)

(67.1–75.9)

(55.5–65.9)

(60.2–69.6)

(52.5–61.0)