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Table 1 Baseline clinical characteristics and laboratory parameters according to the 28-day outcome

From: Neutrophil-to-lymphocyte ratio is associated with 28-day mortality in patients with severe fever with thrombocytopenia syndrome

Variable

Survival

(n = 158)

Non-survival

(n = 24)

P Value

Demographics

   

 Age, years

58.32 ± 12.36

68.29 ± 12.00

0.001

 Male, sex, n (%)

79 (50.0)

9 (37.5)

0.254

Chronic comorbidities

   

 HTN, n (%)

33 (20.9)

9 (37.5)

0.072

 DM, n (%)

9 (5.7)

4 (16.7)

0.052

 COPD, n (%)

1 (0.6)

1 (4.2)

0.620

 CAD, n (%)

1 (0.6)

1 (4.2)

0.620

Clinical manifestations

   

 Fever, n (%)

156 (98.7)

23 (95.8)

0.857

 Vomiting, n (%)

29 (18.4)

7 (29.2)

0.215

 Diarrhea, n (%)

40 (25.3)

7 (29.2)

0.688

 Headache, n (%)

56 (35.4)

6 (25.0)

0.315

 Abdominal pain, n (%)

17 (10.8)

1 (4.2)

0.521

 Cough, n (%)

27 (17.1)

3 (12.5)

0.788

 Lymphadenop athy, n (%)

62 (39.2)

6 (25.0)

0.179

 Petechiae, n (%)

22 (13.9)

6 (25.0)

0.161

 GCS scores, mean ± SD

13.88 ± 2.12

9.50 ± 2.75

0.001

Laboratory parameters

   

 WBC count, mean ± SD, ×109/L

3.57 ± 2.12

5.06 ± 3.69

0.014

 ANC, mean ± SD, ×109/L

2.00 ± 1.71

4.28 ± 3.42

0.004

 ALC, mean ± SD, ×109/L

1.14 ± 0.69

0.89 ± 0.66

0.097

 NLR, mean ± SD, ×109/L

2.13 ± 1.83

6.91 ± 6.73

0.002

 RDW, mean ± SD, %

13.16 ± 0.86

14.00 ± 2.28

0.087

 PLT count, median (IQR), ×109/L

57.5 (37.50, 86.00)

35.50 (25.00, 48.25)

0.001

 PT, mean ± SD, s

11.30 ± 1.02

12.64 ± 3.02

0.051

 APTT, mean ± SD, s

36.60 ± 9.56

59.31 ± 17.09

0.001

 ALT, median (IQR), U/L

72.05 (48.53, 121.40)

62.00 (42.70, 85.80)

0.241

 AST, median (IQR), U/L

112.00 (66.95, 232.25)

241.70 (129.13, 547.03)

0.001

 LDH, median (IQR), U/L

717.50 (422.5, 1221.00)

2110.50 (1109.75, 3575.00)

0.001

 TBil, median (IQR), μmol/L

10.10 (6.95, 16.85)

8.10 (5.90, 15.30)

0.295

 DBil, median (IQR), μmol/L

4.20 (2.55, 6.25)

4.20 (2.45, 9.25)

0.846

 SCr, mean ± SD, μmol/L

59.78 ± 36.11

101.79 ± 60.35

0.003

 BUN, median (IQR), mmol/L

3.60 (2.75, 4.70)

5.80 (4.63, 8.46)

0.001

Complications

   

 MODS, n (%)

28 (17.7)

23 (95.8)

0.001

Duration of hospital

   

 Length of hospital stay, median (IQR) days

10.00 (7.00,12.25)

5.50 (2.00, 11.25)

0.001

  1. ANC absolute neutrophil count, ALC absolute lymphocyte count, AST aspartate aminotransferase, ALT alanine aminotransferase, APTT activated partial thromboplastin time, BUN blood urea nitrogen, CI confidence interval, COPD chronic obstructive pulmonary disease, CAD coronary artery disease, DBil direct bilirubin, DIC disseminated intravascular coagulation, DM diabetes mellitus, GCS glasgow coma scale, HTN hypertension, LDH lactate dehydrogenase, MODS multiple organ dysfunction syndrome, NLR neutrophil-to-lymphocyte ratio, OR odds ratio, PLT platelet, PT prothrombin time, RDW red cell volume distribution width, SCr serum creatinine, TBil total bilirubin, UA uric acid, WBC white blood cell
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BMC Infectious Diseases

ISSN: 1471-2334

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