Skip to main content

Table 2 Predictors of cure

From: Prognostic accuracy of time to sputum culture conversion in predicting cure in extensively drug-resistant tuberculosis patients: a multicentre retrospective observational study

Variable

Cured

No. (%)

Univariate analysis OR (95%CI)

p-value

Multivariate analysis OR (95%CI)

p-value

Gender

     

 Female

 Male

73 (43.5)

73 (39)

Referent

0.833 (0.546–1.273)

0.399

  

Age (years)

     

 ≤ 40

 > 40

112 (43.6)

34 (34.7)

Referent

0.688 (0.424–1.115)

0.129

Referent

0.990 (0.488–2.009)

0.979

Baseline body weight (kg)

     

 < 40

 ≥ 40

42 (33.9)

104 (45)

Referent

1.599 (1.016–2.516)

0.042

Referent

1.661 (0.922–2.994)

0.091

Marital status

     

 Single

 Married

 Widow

54 (47.4)

90 (38.6)

2 (25)

Referent

0.699 (0.445–1.099)

0.370 (0.072–1.913)

0.121

0.236

Referent

0.737 (0.394–1.378)

0.396 (0.045–3.484)

0.339

0.404

History of TB treatment

     

 No

 Yes

14 (58.3)

132 (39.9)

Referent

0.474 (0.204–1.098)

0.082

Referent

0.527 (0.186–1.492)

0.228

History of MDR-TB treatment

     

 No

 Yes

97 (42.2)

49 (39.2)

Referent

0.884 (0.567–1.379)

0.587

  

Baseline sputum smear grading

     

 Negative

 Scanty* + 1†

 + 2‡ + 3§

 Not available

27 (48.2)

51 (46.4)

67 (75.7)

1 (20)

Referent

0.928 (0.487–1.768)

0.615 (0.336–1.125)

0.269 (0.028–2.558)

0.821

0.115

0.253

Referent

1.144 (0.491–2.665)

0.603 (0.276–1.318)

0.709 (0.061–8.238)

0.756

0.205

0.783

Co-morbidity

     

 No

 Yes

120 (40.1)

26 (46.4)

Referent

1.293 (0.728–2.295)

0.380

  

Number of resistant drugs

     

 4–6

 7–8

 > 8

46 (46)

54 (32.5)

46 (51.7)

Referent

0.566 (0.340–0.943)

1.256 (0.709–2.226)

0.029

0.435

Referent

0.523 (0.257–1.066)

1.010 (0.365–2.791)

0.075

0.985

Resistance to all five FLD

     

 No

 Yes

79 (37.3)

67 (46.9)

Referent

1.484 (0.965–2.283)

0.072

Referent

1.798 (0.760–2.674)

0.058

Resistance to ethambutol

     

 No

 Yes

39 (42.4)

107 (40.7)

Referent

0.932 (0.576–1.508)

0.775

  

Resistance to pyrazinamide

     

 No

 Yes

43 (41)

103 (41.2)

Referent

1.010 (0.536–1.606)

0.965

  

Resistance to streptomycin

     

 No

 Yes

53 (37.9)

93 (43.3)

Referent

1.251 (0.810–1.934)

0.313

  

Resistance to ethionamide

     

 No

 Yes

127 (41)

19 (42.2)

Referent

1.053 (0.559–1.984)

0.873

  

Resistance to SLIs

     

 No

 Yes

85 (43.4)

61 (38.4)

Referent

0.813 (0.531–1.245)

0.341

  

Use of moxifloxacin

     

 No

 Yes

46 (39.0)

100 (42.2)

Referent

1.142 (0.728–1.793)

0.563

  

Use of para-amino salicylic acid

     

 No

 Yes

11(27.5)

135 (42.9)

Referent

1.977 (0.954–4.099)

0.067

Referent

1.539 (0.620–3.823)

0.330

Use of clarithromycin

     

 No

 Yes

64 (43.8)

82 (39.2)

Referent

0.827 (0.539–1.270)

0.386

  

Use of co-amoxiclav

     

 No

 Yes

47 (39.5)

99 (41.9)

Referent

1.107 (0.706–1.735)

0.657

  

Use of bedaquiline

     

 No

 Yes

135 (41.9)

11 (33.3)

Referent

0.693 (0.325–1.476)

0.342

  

Use of clofazimine

     

 No

 Yes

71 (43.3)

75 (39.3)

Referent

0.847 (0.554–1.294)

0.442

  

Use of linezolid

     

 No

 Yes

43 (45.7)

103 (42.2)

Referent

1.155 (0.730–1.827)

0.538

  

Use of amikacin

     

 No

 Yes

117 (41.2)

29 (40.8)

Referent

0.986 (0.581–1.673)

0.957

  

Use of capreomycin

     

 No

 Yes

38 ( 40.4)

108 (41.4)

Referent

1.040 (0.644–1.681)

0.872

  

Use of high dose isoniazid

     

 No

 Yes

138 (43.1)

8 (22.9)

Referent

0.391 (0.172–0.887)

0.025

Referent

0.433 (0.57–1.195)

0.106

Use of ethambutol

     

 No

 Yes

118 (40.7)

28 (43.1)

Referent

1.103 (0.640–1.900)

0.724

  

SCC at month 2

     

 No

 Yes

85 (32.9)

61 (62.9)

Referent

3.449 (2.119–5.612)

 < 0.001

Referent

0.658 (0.310–1.394)

0.274

SCC at month 4

     

 No

 Yes

44 (22)

102 (65.8)

Referent

6.823 (4.259–10.931)

 < 0.001

Referent

1.037 (0.388–2.773)

0.942

SCC at month 6

     

 No

 Yes

21 (12.7)

125 (66.1)

Referent

12.770 (7.348–21.923)

 < 0.001

Referent

15.603 (6.168–39.467)

 < 0.001

  1. *Scanty = 1–9 AFB (Acid fast bacilli)/100 HPF (High power field); † + 1 = 10–99 AFB/100 HPF); ‡ + 2 = 1–9 AFB/HPF; § + 3 > 9 AFB/HPF, CI = Confidence interval; FLD = First line anti-TB drugs; OR = Odds ratio, SCC = Sputum culture conversion; SLD = Second line anti-TB drugs