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Table 4 Effect of age, sex, and medical history on the presence of each adverse reaction

From: Impact of age, sex and medical history on adverse reactions to the first and second dose of BNT162b2 mRNA COVID-19 vaccine in Japan: a cross-sectional study

 

Age

Sex

Medical history

First vaccination

Second vaccination

First vaccination

Second vaccination

First vaccination

Second vaccination

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

Injection site reaction

0.72 (0.60–0.86)**

0.85 (0.72–0.99)*

1.71 (1.09–2.68)*

1.36 (0.93–2.01)

1.86 (0.86–4.00)

1.13 (0.61–2.11)

Fatigue

0.90 (0.77–1.05)

0.83 (0.71–0.97)*

1.57 (1.06–2.32)*

1.74 (1.19–2.54)**

1.17 (0.63–2.17)

1.29 (0.70–2.38)

Chills

0.31 (0.12–0.82)*

0.76 (0.60–0.97)*

0.41 (0.12–1.45)

2.34 (1.32–4.17)**

N/A

0.94 (0.37–2.39)

Fever

0.57 (0.30–1.09)

0.74 (0.61–0.89)**

0.35 (0.10–1.20)

1.79 (1.13–2.82)*

N/A

1.27 (0.61–2.61)

Arthralgia

0.77 (0.60–0.98)*

0.82 (0.69–0.97)*

1.00 (0.57–1.75)

1.88 (1.24–2.87)**

1.62 (0.69–3.82)

1.40 (0.73–2.69)

Myalgia

0.84 (0.67–1.05)

0.77 (0.63–0.94)**

1.39 (0.81–2.39)

1.88 (1.16–3.04)*

1.50 (0.67–3.36)

1.51 (0.73–3.15)

Headache

0.76 (0.62–0.93)**

0.77 (0.66–0.91)**

1.58 (0.98–2.57)

2.27 (1.53–3.37)**

1.25 (0.58–2.71)

1.37 (0.73–2.57)

Diarrhea

0.78 (0.47–1.28)

0.47 (0.28–0.79)**

0.85 (0.28–2.56)

0.80 (0.31–2.03)

0.81 (0.10–6.69)

4.41 (1.26–15.43)*

Nausea

0.64 (0.43–0.95)*

0.70 (0.54–0.92)*

1.33 (0.57–3.09)

1.54 (0.83–2.87)

1.64 (0.45–6.03)

1.49 (0.57–3.86)

Vomiting

0.57 (0.22–1.52)

0.77 (0.45–1.31)

1.11 (0.18–6.74)

1.31 (0.38–4.54)

N/A

2.29 (0.44–11.94)

Any adverse event

0.67 (0.53–0.83)**

0.62 (0.49–0.78)**

2.10 (1.17–3.75)*

2.11 (1.16–3.82)*

2.16 (0.81–5.77)

2.30 (0.85–6.22)

  1. Logistic regression was performed. OR odds ratio, CI confidence interval. *p < 0.05, **< p < 0.01
  2. OR and 95% CI of age show ratio per 10 years. OR and 95% CI of sex show ratio of female to male. OR and 95% CI of medical history show ratio of those with a medical history to those without. All the statistics were adjusted for age, sex, and medical history