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Table 3 Effect of age or sex on the presence of each adverse reaction

From: Impact of age, sex and medical history on adverse reactions to the first and second dose of BNT162b2 mRNA COVID-19 vaccine in Japan: a cross-sectional study

 

Age

Sex

First vaccination

Second vaccination

First vaccination

Second vaccination

OR (95%CI)

OR (95%CI)

OR (95%CI)

OR (95%CI)

Injection site reaction

0.75 (0.63–0.88)**

0.85 (0.73–0.98)*

1.72 (1.10–2.67)*

1.38 (0.94–2.03)

Fatigue

0.90 (0.78–1.05)

0.84 (0.73–0.97)*

1.58 (1.07–2.33)*

1.75 (1.20–2.55)**

Chills

0.30 (0.12–0.76)*

0.76 (0.61–0.95)*

0.41 (0.12–1.44)

2.37 (1.33–4.20)**

Fever

0.52 (0.28–0.98)*

0.75 (0.62–0.90)**

0.36 (0.11–1.22)

1.80 (1.15–2.81)*

Arthralgia

0.80 (0.63–1.01)

0.83 (0.71–0.98)*

1.01 (0.58–1.76)

1.88 (1.24–2.86)**

Myalgia

0.86 (0.70–1.07)

0.79 (0.65–0.95)*

1.39 (0.81–2.38)

1.88 (1.17–3.03)**

Headache

0.77 (0.63–0.93)**

0.79 (0.68–0.92)**

1.60 (0.99–2.58)

2.27 (1.54–3.34)**

Diarrhea

0.77 (0.47–1.25)

0.55 (0.33–0.89)*

0.86 (0.28–2.60)

0.82 (0.33–2.05)

Nausea

0.66 (0.45–0.97)*

0.73 (0.56–0.94)*

1.34 (0.58–3.10)

1.55 (0.84–2.87)

Vomiting

0.54 (0.21–1.40)

0.82 (0.49–1.36)

1.11 (0.18–6.73)

1.31 (0.38–4.52)

Any adverse event

0.69 (0.56–0.85)**

0.64 (0.52–0.80)**

2.13 (1.20–3.75)**

2.15 (1.21–3.83)**

  1. Logistic regression was performed. OR odds ratio, CI confidence interval. *p < 0.05, **p < 0.01
  2. OR and 95% CI of age show ratio per 10 years. OR and 95% CI of Sex show ratio of female to male