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Table 2 Determinants associated with suboptimal CD4 + count recovery among Yi patients with sustained HIV suppression on ART

From: Determinants of suboptimal immune recovery among a Chinese Yi ethnicity population with sustained HIV suppression

 

CD4 + cell count > 200 cells/mL

CD4 + cell count > 350 cells/mL

CD4 + cell count > 500 cells/mL

aOR (95% CI)

p value

aOR (95% CI)

p value

aOR (95% CI)

p value

Age category (years)

 18–29

Reference

 

Reference

 

Reference

 

 30–39

1.186 (0.289–4.871)

0.812

0.698 (0.327–1.489)

0.352

1.001 (0.497–2.016)

0.998

 40–49

1.257 (0.280–5.650)

0.765

0.684 (0.293–1.596)

0.380

0.694 (0.307–1.569)

0.380

 ≥ 50

1.081 (0.080–14.645)

0.954

0.462 (0.119–1.793)

0.265

0.847 (0.203–3.530)

0.820

 Male sex

2.272 (0.791–6.524)

0.127

1.258 (0.681–2.321)

0.464

1.908 (1.017–3.580)

0.044

Pre-ART CD4 + count

 < 100

0.710 (0.101–4.991)

0.730

1.140 (0.285–4.559)

0.853

0.478 (0.245–0.874)

0.017

 100–199

Reference

 

0.707 (0.356–1.402)

0.321

0.421(0.871–0.895)

0.022

 200–350

  

Reference

 

0.422 (0.212–0.839)

0.014

 350–500

    

Reference

 

Pre-ART CD4/CD8 ratio

 > 0.45

Reference

 

Reference

 

Reference

 

 0.30–0.45

0.062 (0.006–0.603)

0.017

0.824 (0.347–1.959)

0.661

0.635 (0.289–1.398)

0.260

 < 0.30

0.164 (0.017–1.624)

0.122

0.704 (0.306–1.617)

0.408

0.655 (0.302–1.422)

0.284

HIV viral load (copies/ml)

 < 100 000

Reference

 

Reference

 

Reference

 

 > 100 000

0.746 (0.229–2.434)

0.628

0.604 (0.295–1.236)

0.168

0.935 (0.473–1.848)

0.846

BMI (kg/m2)

      

 < 18.5

0.844 (0.242–2.943)

0.790

0.399 (0.173–0.920)

0.031

0.749 (0.300–1.871)

0.536

 18.5–24

Reference

 

Reference

 

Reference

 

 > 28

0.814 (0.263–2.367)

0.998

1.359 (0.448–4.123)

0.588

0.822 (0.257–2.625)

0.740

 HBsAg positive

9.098 (0.964–85.897)

0.054

1.445 (0.584–3.577)

0.426

1.299 (0.569–2.965)

0.534

 Anti-HCV positive

0.215 (0.073–0.633)

0.005

0.453 (0.245–0.834)

0.011

0.261 (0.095–0.716)

0.009

WHO clinical stage

      

 I and II

Reference

 

Reference

 

Reference

 

 III and IV

0.104 (0.010–1.045)

0.054

0.541 (0.108–2.703)

0.454

1.197 (0.227–6.303)

0.832

 Treatment duration > 3 years

0.555 (0.192–1.602)

0.277

0.552 (0.304–1.001)

0.050

0.900 (0.502–1.614)

0.725

 Leucocyte < 4 or > 10 × 109/L

1.408 (0.318–6.243)

0.653

1.295 (0.552–3.034)

0.552

1.451 (0.621–3.389)

0.389

 Platelet < 100 × 109/L

2.125 (0.433–10.432)

0.353

0.589 (0.249–1.393)

0.228

0.892 (0.347–2.296)

0.813

 Anemia

0.445 (0.104–1.906)

0.275

0.836 (0.341–2.049)

0.695

0.856 (0.327–2.243)

0.752

 TBil > 17.1 µmol/L

0.979 (0.333–2.883)

0.970

1.663 (0.841–3.289)

0.144

1.824 (0.945–3.520)

0.073

 ALT > 40 U/L

0.914 (0.255–3.273)

0.890

1.159 (0.525–2.560)

0.715

1.136 (0.512–2.524)

0.753

 AST > 40 U/L

0.617 (0.179–2.127)

0.444

1.225 (0.570–2.629)

0.603

1.084 (0.503–2.337)

0.837

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BMC Infectious Diseases

ISSN: 1471-2334

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