“H” is not for hydroxychloroquine—“H” is for heparin: lack of efficacy of hydroxychloroquine and the role of heparin in COVID-19—preliminary data of a prospective and interventional study from Brazil

Table 4 Association between clinical factors related to increased risk of death and increased risk of ICU admission in patients with COVID-19

Clinical features associated with death	β value	Hazard ratio	95% Confidence interval	P value
Age ≥ 61 years	1.218	3.379	2.015–5.666	< 0.001
Heparin (use)	− 1.372	0.254	0.113–0.569	0.001
Intensive Care Unit (ICU)	2.195	8.980	2.168–37.190	0.002
Gastrointestinal symptoms	− 0.905	0.404	0.160–1.023	0.056

Clinical features associated with ICU admission	β value	Hazard ratio	95% Confidence interval	P value
Age ≥ 61 years	0.599	1.820	1.245–2.660	0.002
Heparin (use)	− 0.776	0.460	0.200–1.059	0.068
Neurological diseases	0.777	2.029	0.965–4.263	0.062
Oseltamivir	− 0.363	0.695	0.446–1.085	0.110

Multivariate analysis for risk of death and for ICU admission in COVID-19 patients by Cox Regression or Proportional Risk Model