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Table 1 Baseline characteristics of the study participants treated with AS-AQ and AL using the ITT population

From: Effectiveness and safety of artesunate–amodiaquine versus artemether–lumefantrine for home-based treatment of uncomplicated Plasmodium falciparum malaria among children 6–120 months in Yaoundé, Cameroon: a randomized trial

Characteristic/Category

AS-AQ (n = 114, %)

AL (n = 128, %)

P-value*

Gender ratio (Male: Female)

46:68

56:72

0.593

Age group (months)

   

  < 60

56 (49.1)

55 (43.0)

0.338

 60120

58 (50.9)

73 (57.0)

 

 Median (IQR)

58.5 (50)

64.5 (54)

0.660

 Range (min, max)

(6120)

(8120)

 

Heart rate (beats per minute)

   

 Median (IQR)

100 (15)

100 (18)

0.839

 Range (min, max)

(24164)

(40150)

 

Systolic blood pressure (mm/Hg)

   

 Median (IQR)

100 (10)

100 (10)

0.476

 Range (min, max)

(70157)

(70158)

 

Diastolic blood pressure (mm/Hg)

   

 Median (IQR)

60 (10)

60 (10)

0.657

 Range (min, max)

(4090)

(36140)

 

Respiratory rate (breaths per minute)

   

 Median (IQR)

30 (7)

30 (9)

0.411

 Range (min, max)

(1478)

(1660)

 

Body weight (Kg)

   

 Median (IQR)

19.0 (9.1)

20.0 (8.8)

0.902

 Range (min, max)

(7.733.0)

(6.948.0)

 

Axillary temperature (°C)

   

 Median (IQR)

37.2 (0.8)

37.4 (1.1)

0.982

 Range (min, max)

(35.740.0)

(35.640.2)

 

Hemoglobin concentration (g/dl)

   

 Mean \(\pm\) SD

10.4 \(\pm\) 1.7

10.6 \(\pm\) 1.6

0.196

 Range (min, max)

(5.613.6)

(5.815.4)

 

Parasitemia (parasites/µl)

   

 GMPD

3940

4259

0.736

 Range (min, max)

(79331,131)

(79575,440)

 

Total bilirubin (mg/dl)

   

 Median (IQR)

0.0478 (0.0851)

0.0657 (0.0968)

0.150

 Range (min, max)

(0.00060.7640)

(0.00160.6100)

 

Aspartate aminotransferase (U/L)

   

 Median (IQR)

42.5100 (27.0700)

40.1845 (18.0330)

0.237

 Range (min, max)

(11.8870173.6800)

(1.9759141.5700)

 

Alanine aminotransferase (U/L)

   

 Median (IQR)

21.5400 (14.2800)

22.0220 (10.5990)

0.754

 Range (min, max)

(3.8954109.0800)

(3.6267371.9800)

 

Creatinine (mg/dl)

   

 Median (IQR)

0.4858 (0.2059)

0.5130 (0.2211)

0.566

 Range (min, max)

(0.155810.6600)

(0.18450.9954)

 
  1. n  Number of participants enrolled into the AS-AQ and AL drug arms on day 0, SD  Standard deviation, GMPD Geometric mean parasite density, IQR Interquartile range, Min minimum value; Max maximum value, *Determined by using Student t independent test, MannWhitney U test or Pearson chi-square test