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Table 3 Antibiotic resistance rates (% of isolates intermediate or resistant to the antibiotic listed) of Gram-negative bacterial isolates (only species for which n > 30) and proportion of isolates showing specific antibiotic resistance patterns and mechanisms

From: Blood culture surveillance in a secondary care hospital in Benin: epidemiology of bloodstream infection pathogens and antimicrobial resistance

Antibiotic

Enterobacter cloacae

n = 44

Escherichia coli

n = 49*

Klebsiella pneumoniae

n = 58*

Salmonella Typhi

n = 53*

Antibiotic susceptibility rates (% susceptible)

 Ampicillin

73.5%

30.2%

 Amoxicillin-clavulanic acid

41.7%

81.0%

 Piperacillin-tazobactam

16.3%

18.7%

25.9%

 Cefuroxime

72.7%

40.8%

79.3%

 Ceftriaxone

70.5%

12.8%

77.6%

0%

 Temocillin

7.0%

11.0%

0%

 Meropenem

4.5%

4.1%

0%

0%

 Ciprofloxacin

75.0%

35.4%

70.7%

24.5%

 Trimethoprim-sulfamethoxazole

76.7%

36.7%

15.5%

39.6%

 Gentamicin

68.2%

24.5%

74.1%

0%

 Amikacin

2.3%

0%

3.4%

 Chloramphenicol

65.9%

24.5%

37.9%

39.6%

 Azithromycin

0%

Antibiotic resistance mechanisms and patterns

 ESBL

68.2%

28.6%

79.3%

0%

 Carbapenemase

4.5%

4.1%

0%

0%

 Combined resistance carbapenems–fluoroquinolones

2.3%

2.0%

0%

0%

 MDR**

79.5%

69.4%

87.9%

39.6%

 XDR**

22.7%

8.2%

32.8%

0%

 PDR**

2.3%

2.0%

0%

0%

 DCS**

24.5%

  1. ESBL extended spectrum beta-lactamase; DCS decreased ciprofloxacin susceptibility; MDR multidrug resistance; XDR extensive drug resistance; PDR pan-drug resistance
  2. *Isolate numbers do not always correspond with pathogens retrieved from cultures as depicted in Fig. 2, because some cultures contained morphologically different isolates of the same species. These were counted as different isolates in the antibiotic susceptibility analysis when their antibiotic susceptibility patterns differed, but not in the overall analysis of key pathogens
  3. **MDR, XDR and PDR are defined according to Magiorakos et al., except for Salmonella species [26]. For Salmonella species, MDR is defined as resistance against ampicillin, co-trimoxazole and chloramphenicol; XDR is defined as resistance to ampicillin, co-trimoxazole, chloramphenicol, third generation cephalosporins and azithromycin [27]. Decreased ciprofloxacin resistance is defined as MIC ciprofloxacin > 0.06 but < 0.5 [20]