Table 4 Genes mentioned twice or more in the reviewed studies and the according related SNPs mentioned
Gene | Related SNPs | Role of the gene |
|---|---|---|
ACE2 (angiotensin I converting enzyme 2) | rs75603675, rs2285666, rs879922, rs73635825, rs143936283, rs143936283 rs267606406 rs4646116, rs149039346, rs147311723, rs714205, rs1514283, rs4646175, rs3746444, rs113808830, rs3751304, rs112657409, rs11910678, rs77675406, rs713400, rs13015258, rs12329760, rs775181355, rs762890235, rs35803318, rs41303171, rs774469453, rs773676270, rs2285666, rs146598386, rs73195521, rs755766792, rs2285666, rs6598045 | SARS-CoV-2 spike protein entry receptor [15] |
IFITM3 (interferon-induced transmembrane protein 3) | rs12252-C, rs6598045 | Gene variants of IFITM3 are related to the infection of influenza and viruses. IFITM3 is significant in taking antiviral actions. It prevents cellular lipid bilayer from getting bisected by viruses [7]. Immune effector protein that is significant to the restriction of a virus is encoded by IFITM3. Also, membrane restriction is done by IFITM3 [8] |
TMPRSS2 (transmembrane protease, serine 2) | rs61735794, rs61735792, rs75603675, rs112657409, rs11910678, rs77675406, rs713400, rs13015258, rs12329760 | Cleavage of TMPRSS2 activates influenza virus hemagglutinin and the human metapneumovirus F protein [3] |