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Table 2 Effect of maternal vitamin D supplementation on relative hazard of pneumococcal acquisition and pneumococcal density

From: Effect of maternal vitamin D supplementation on nasal pneumococcal acquisition, carriage dynamics and carriage density in infants in Dhaka, Bangladesh

 

Vitamin D supplementation group: prenatal; postpartum dose (IU/week)

A: 0;0

B: 4200;0

C: 16,800;0

D: 28,000;0

E: 28,000;28,000

Number of infants with ≥ 1 nasal swabA

206

218

208

216

212

Infants ever positive for detection of nasal pneumococcal carriage

(≥ 1 positive swab) (%)

186 (90%)

188 (86%)

191 (92%)

193 (89%)

190 (90%)

Relative hazard of pneumococcal acquisition (95% CI)B

REFE

0.87 (0.70, 1.08)

1.16 (0.94, 1.44)

1.05 (0.85, 1.30)

1.05 (0.84, 1.30)

Median time until 1st detection of pneumococcal carriage (weeks)B

7.1

8.1

6.2

6.8

6.8

Positive swabs in pneumococcal density analysis (N)C

500

501

560

555

499

Pneumococcal density: percent difference (95% CI)D

REFE

− 9.7 (− 39, 33)

− 10.7 (− 40, 34)

− 3.4 (− 34, 42)

− 8.9 (− 39, 36)

  1. AN = 1060
  2. BEstimated using interval-censored parametric modelling assuming a Gompertz distribution
  3. COverall number of positive swabs in each group are the same values
  4. DEstimated using log-transformed density data using GEE and robust standard errors to accommodate repeated measurements from the same infants. Analysis based on only samples with detectable pneumococcus
  5. EREF indicates that group A (0;0) was the reference group for other estimates