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Table 4 Multivariate logistic regression analysis for in-hospital mortality with unadjusted and adjusted odds ratios and 95% confidence intervals

From: Burden of illness in carbapenem-resistant Acinetobacter baumannii infections in US hospitals between 2014 and 2019

Risk factor

Unadjusted OR (95% CI)

P value

Adjusted OR (95% CI)

P value

Age group (reference group age 18–35)

    

 36–55

1.73 (1.09; 2.73)

0.02

1.67 (1.03; 2.71)

0.04

 56–75

3.33 (2.16; 5.14)

 < 0.01

2.45 (1.54; 3.91)

 < 0.01

 > 75

4.33 (2.76; 6.79)

 < 0.01

3.53 (2.17; 5.74)

 < 0.01

Sex

    

 Male vs female

0.87 (0.74; 1.02)

0.09

0.94 (0.79; 1.13)

0.51

Race (reference group “black”)

    

 White

1.15 (0.94; 1.42)

0.18

1.14 (0.91; 1.43)

0.27

 Other

1.47 (1.11; 1.96)

0.01

1.57 (1.15; 2.15)

 < 0.01

 Unknown

0.79 (0.36; 1.76)

0.57

0.56 (0.24; 1.31)

0.18

Infection site (reference group “Urine”)

    

 Blood

4.27 (2.90; 6.28)

 < 0.01

3.82 (2.56; 5.71)

 < 0.01

 Respiratory

5.37 (3.76; 7.68)

 < 0.01

2.66 (1.80; 3.92)

 < 0.01

 Wound

0.85 (0.57; 1.28)

0.44

0.89 (0.58; 1.34)

0.57

 Other

1.13 (0.64; 1.99)

0.67

0.99 (0.55; 1.78)

0.98

Days between admission and index culture (prior to admission)

    

 Same day as admission

1.29 (0.76; 2.19)

0.34

0.88 (0.5; 1.55)

0.66

 2 days

1.27 (0.73; 2.21)

0.41

0.78 (0.42; 1.43)

0.42

 3 days

1.75 (0.96; 3.19)

0.07

0.96 (0.50; 1.86)

0.92

 4 days

2.20 (1.16; 4.16)

0.02

1.23 (0.61; 2.47)

0.56

 5 days

2.45 (1.28; 4.67)

0.01

1.12 (0.55; 2.27)

0.76

 ≥ 6 days

3.41 (2.01; 5.79)

 < 0.01

1.57 (0.87; 2.81)

0.13

CCI group (reference group CCI = 0)

    

 1

1.52 (0.99; 2.33)

0.06

1.10 (0.70; 1.72)

0.69

 2

1.82 (1.22; 2.72)

 < 0.01

1.37 (0.90; 2.11)

0.14

 3–5

2.54 (1.77; 3.63)

 < 0.01

1.72 (1.17; 2.54)

0.01

 > 5

4.31 (2.98; 6.21)

 < 0.01

2.73; (1.83; 4.08)

 < 0.01

Admission source (reference group “Home”)

    

 Nursing

1.72 (1.29; 2.31)

 < 0.01

1.22 (0.88; 1.68)

0.23

 Transferred from other facilities

1.39 (1.15; 1.68)

 < 0.01

1.17 (0.95; 1.45)

0.14

 Other

0.48 (0.21; 1.09)

0.08

0.63 (0.26; 1.51)

0.30

Infection associated ICU utilization

    

 Yes vs no

4.77 (4.01; 5.68)

 < 0.01

2.93 (2.40; 3.57)

 < 0.01

Carbapenem susceptibility status

    

 CR vs CS

1.77 (1.51; 2.08)

 < 0.01

1.42 (1.15; 1.75)

 < 0.01

Patient received any active drug within 72 h of index culture date

    

 No active antibiotica vs active antibioticb

1.16 (0.98; 1.36)

0.08

1.03 (0.84; 1.27)

0.77

  1. CCI Charlson Comorbidity Index, CI Confidence interval, CR Carbapenem resistant, CS Carbapenem susceptible, ICU intensive care unit, OR odds ratio
  2. aThe antibiotic is considered as “active” if Acinetobacter baumannii was “susceptible” based on susceptibility testing result. The category included tigecycline and colistin without available susceptibility testing result
  3. bThe antibiotic is considered as “not active” if Acinetobacter baumannii was “resistant” or “intermediate” based on susceptibility testing result or if antibiotics were not tested for susceptibility or the missing testing results cannot be imputed based on the algorithm in Additional file 7: Table S6