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Table 3 Risk prediction of circulating biomarkers for the risk of sepsis, as well as the mortality risk

From: Association of mitochondrial respiratory chain enzymes with the risk and mortality of sepsis among Chinese children

Significant risk factors

cOR

95% CI

P

aOR

95% CI

P*

Children with sepsis versus controls

      

 CoQ10 (+ 0.05 μmol/L)

0.88

0.82 to 0.95

0.001

0.85

0.77 to 0.93

0.001

 Complex I (+20 nmol/min.mg)

1.19

0.75 to 1.89

0.456

1.02

0.59 to 1.78

0.942

 Complex II (+50 nmol/min.mg)

0.29

0.10 to 0.85

0.025

0.29

0.10 to 0.85

0.025

 Complex II + III (+50 nmol/min.mg)

0.71

0.39 to 1.28

0.258

0.42

0.20 to 0.90

0.026

 Complex IV (+ 100 nmol/min.mg)

0.69

0.23 to 2.10

0.517

0.25

0.06 to 1.04

0.057

 Complex I + III (+ 50 nmol/min.mg)

0.71

0.61 to 0.83

 < 0.001

0.68

0.57 to 0.82

 < 0.001

 FoF1-ATPase (+ 100 nmol/min.mg)

0.53

0.42 to 0.68

 < 0.001

0.53

0.40 to 0.70

 < 0.001

Children with sepsis: deceased versus survived

 CoQ10 (+ 0.05 μmol/L)

0.74

0.61 to 0.90

0.003

0.73

0.59 to 0.90

0.004

 Complex I (+ 20 nmol/min.mg)

1.35

0.71 to 2.58

0.364

1.38

0.71 to 2.65

0.340

 Complex II (+ 50 nmol/min.mg)

1.30

0.36 to 4.80

0.690

1.32

0.35 to 4.96

0.678

 Complex I + III (+ 50 nmol/min.mg)

0.81

0.37 to 1.77

0.598

0.79

0.33 to 1.85

0.580

 Complex IV (+ 100 nmol/min.mg)

1.15

0.29 to 4.59

0.841

1.14

0.27 to 4.80

0.857

 Complex I + III (+50 nmol/min.mg)

0.79

0.68 to 0.91

0.001

0.76

0.64 to 0.89

0.001

 FoF1-ATPase (+ 100 nmol/min.mg)

1.08

0.87 to 1.35

0.478

1.08

0.87 to 1.35

0.481

  1. cOR crude odds ratio, aOR adjusted odds ratio, 95% CI 95% confidence interval
  2. *P was calculated after adjusting for age and sex. Data are expressed as odds ratio, 95% confidence interval, P value