Biomarkers | Controls | Children with sepsis | P1 | P2 | ||
---|---|---|---|---|---|---|
All | Deceased | Survived | ||||
CoQ10 (μmol/L) | 1.0 (0.8 to 1.2) | 0.7 (0.5 to 1.0) | 0.5 (0.4 to 0.6) | 0.8 (0.6 to 1.1) |  < 0.001 |  < 0.001 |
Complex I (nmol/min.mg) | 107.7 (95.2 to 120.8) | 107.1 (98.8 to 124.4) | 113.8 (98.5 to 125.0) | 106.2 (98.8 to 124.4) | 0.460 | 0.371 |
Complex II (nmol/min.mg) | 99.6 (88.0 to 108.1) | 88.2 (78.8 to 100.7) | 87.1 (70.1 to 98.5) | 91.3 (79.9 to 101.4) | 0.004 | 0.499 |
Complex II + III (nmol/min.mg) | 186.3 (170.2 to 202.7) | 184.9 (158.8 to 199.8) | 186.8 (132.2 to 207.5) | 182.3 (163.6 to 199.6) | 0.260 | 0.606 |
Complex IV (nmol/min.mg) | 136.3 (123.1 to 155.7) | 143.6 (88.1 to 166.6) | 149.2 (88.8 to 164.1) | 132.3 (88.1 to 166.8) | 0.521 | 0.983 |
Complex I + III (nmol/min.mg) | 898.1 (806.9 to 1083.1) | 622.8 (384.7 to 811.9) | 236.8 (132.6 to 592.5) | 731.7 (563.4 to 823.4) |  < 0.001 |  < 0.001 |
FoF1-ATPase (nmol/min.mg) | 751.9 (605 to 903.3) | 356.6 (222.8 to 544.7) | 383.9 (215.3 to 710.8) | 335.2 (222.8 to 535.1) |  < 0.001 | 0.486 |