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Table 2 Subgroup analysis of clinical outcomes by clinical and demographic characteristics

From: Safety and clinical outcomes of remdesivir in hospitalised COVID-19 patients: a retrospective analysis of active surveillance database

Characteristics

N (%)

Cure/improvement

Death/death related to COVID-19

No improvement

Age group (years)

 12–20

4 (80.00)

0 (0.00)

1 (20.00)

 20–40

278 (91.45) #*

11 (3.62) ##**

15 (4.93) ###***

 40–60

826 (85.33) $

52 (5.37) $$

90 (9.30) $$$

 ≥ 60

549 (78.99)

70 (10.07)

75 (10.79)

Gender

 Male

1,206 (83.29) @

108 (7.46) @

134 (9.25) @

 Female

451 (86.07)

26 (4.96)

47 (8.97)

Diabetes

 Yes

489 (78.36)

62 (9.93)

72 (11.54)

 No

1,136 (85.52)

71 (5.41)

106 (8.07)

Hypertension

 Yes

377 (87.06)

23 (5.32)

33 (7.62)

 No

1,248 (82.98)

110 (7.31)

145 (9.64)

Other cardiac conditions

 Yes

105 (81.40)

19 (14.73)

5 (3.88)

 No

1,520 (84.07)

114 (6.31)

173 (9.57)

Lung disease

 Yes

72 (77.42)

10 (10.75)

11 (11.83)

 No

1553 (84.22)

123 (6.67)

167 (9.06)

Received oxygen support

 Yes

1608 (83.62)

134 (6.97)

181 (9.41)

 No

37 (100.00)

0 (0.00)

0 (0.00)

 SLFO

1107 (93.97)

26 (2.21)

45 (3.82)

 HFO

332 (80.58) §§

24 (5.82) §

56 (13.59) §§

 NIV

146 (57.71) §§

48 (18.97) §§

59 (23.32) §§

 MV

23 (28.75) §§

36 (45.00) §§

21 (26.25) §§

Remdesivir treatment time

 < 5 days

312 (75.5) §§§

59 (14.3) §§§

42 (10.2)

 5 days

1095 (87.0)

56 (4.4)

108 (8.6)

 6–10 days

183 (85.9)@@@

14(6.6)@@@

16 (7.5)

 > 10 days

15 (100)

0

0

Received steroids

383 (79.95) @@

40 (8.35) @@

56 (11.69) @@

Received antibiotics

456 (79.31)

52 (9.05)

67 (11.65)

Received anticoagulants

253 (81.35)

19 (6.11)

39 (12.54)

  1. The patient status “No improvement” in the last column was reported at the time of data entry which can eventually change
  2. SLFO standard low-flow oxygen, HFO high-flow oxygen, NIV non-invasive ventilation, MV mechanical ventilation
  3. #p = 0.0083 vs. 40–60 years; *p < 0.0001 vs. > 60 years; $p = 0.0011 vs. > 60 years; ##p = 0.2812 vs. 40–60 years; **p < 0.0001 vs. > 60 years; $$p = 0.0004 vs. > 60 years; ###p = 0.0219 vs. 40–60 years; ***p = 0.004 vs. > 60 years; $$$p = 0.3515 vs. > 60 years; §p = 0.001 vs. SLFO; §§p = 0.0001 vs. SLFO; @p = 0.156 for cure, 0.065 for death, and 0.916 for no improvement; @@ p = 0.112 compared with patients not receiving steroids; §§§p < 0.0001 vs. 5 days; @@@p = 0.004 for cure/improvement and 0.007 for death/death related to COVID-19