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Table 2 Subgroup analysis of clinical outcomes by clinical and demographic characteristics

From: Safety and clinical outcomes of remdesivir in hospitalised COVID-19 patients: a retrospective analysis of active surveillance database

Characteristics N (%)
Cure/improvement Death/death related to COVID-19 No improvement
Age group (years)
 12–20 4 (80.00) 0 (0.00) 1 (20.00)
 20–40 278 (91.45) #* 11 (3.62) ##** 15 (4.93) ###***
 40–60 826 (85.33) $ 52 (5.37) $$ 90 (9.30) $$$
 ≥ 60 549 (78.99) 70 (10.07) 75 (10.79)
Gender
 Male 1,206 (83.29) @ 108 (7.46) @ 134 (9.25) @
 Female 451 (86.07) 26 (4.96) 47 (8.97)
Diabetes
 Yes 489 (78.36) 62 (9.93) 72 (11.54)
 No 1,136 (85.52) 71 (5.41) 106 (8.07)
Hypertension
 Yes 377 (87.06) 23 (5.32) 33 (7.62)
 No 1,248 (82.98) 110 (7.31) 145 (9.64)
Other cardiac conditions
 Yes 105 (81.40) 19 (14.73) 5 (3.88)
 No 1,520 (84.07) 114 (6.31) 173 (9.57)
Lung disease
 Yes 72 (77.42) 10 (10.75) 11 (11.83)
 No 1553 (84.22) 123 (6.67) 167 (9.06)
Received oxygen support
 Yes 1608 (83.62) 134 (6.97) 181 (9.41)
 No 37 (100.00) 0 (0.00) 0 (0.00)
 SLFO 1107 (93.97) 26 (2.21) 45 (3.82)
 HFO 332 (80.58) §§ 24 (5.82) § 56 (13.59) §§
 NIV 146 (57.71) §§ 48 (18.97) §§ 59 (23.32) §§
 MV 23 (28.75) §§ 36 (45.00) §§ 21 (26.25) §§
Remdesivir treatment time
 < 5 days 312 (75.5) §§§ 59 (14.3) §§§ 42 (10.2)
 5 days 1095 (87.0) 56 (4.4) 108 (8.6)
 6–10 days 183 (85.9)@@@ 14(6.6)@@@ 16 (7.5)
 > 10 days 15 (100) 0 0
Received steroids 383 (79.95) @@ 40 (8.35) @@ 56 (11.69) @@
Received antibiotics 456 (79.31) 52 (9.05) 67 (11.65)
Received anticoagulants 253 (81.35) 19 (6.11) 39 (12.54)
  1. The patient status “No improvement” in the last column was reported at the time of data entry which can eventually change
  2. SLFO standard low-flow oxygen, HFO high-flow oxygen, NIV non-invasive ventilation, MV mechanical ventilation
  3. #p = 0.0083 vs. 40–60 years; *p < 0.0001 vs. > 60 years; $p = 0.0011 vs. > 60 years; ##p = 0.2812 vs. 40–60 years; **p < 0.0001 vs. > 60 years; $$p = 0.0004 vs. > 60 years; ###p = 0.0219 vs. 40–60 years; ***p = 0.004 vs. > 60 years; $$$p = 0.3515 vs. > 60 years; §p = 0.001 vs. SLFO; §§p = 0.0001 vs. SLFO; @p = 0.156 for cure, 0.065 for death, and 0.916 for no improvement; @@ p = 0.112 compared with patients not receiving steroids; §§§p < 0.0001 vs. 5 days; @@@p = 0.004 for cure/improvement and 0.007 for death/death related to COVID-19