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Table 3 Prognostic accuracy of vital signs and clinical scores alone and in combination with selected biomarkers (those with an area under the receiver-operating characteristic curve > 0.80) for predicting community-acquired pneumonia with a bacterial pathogen detected among those presenting with a lower respiratory tract infection at outpatient clinics in Tanzania

From: Clinical sign and biomarker-based algorithm to identify bacterial pneumonia among outpatients with lower respiratory tract infection in Tanzania

Model Clinical parameter ( +) PCT ( +) IL-6 ( +) sTREM1
Respiratory rate 0.82 (0.72–0.92) 0.95 (0.91–1.00)** 0.90 (0.81–0.98)* 0.89 (0.83–0.95)
Saturation 0.83 (0.75–0.91) 0.90 (0.81–0.98) 0.89 (0.81–0.96) 0.85 (0.77–0.94)
Systolic blood pressure 0.79 (0.67–0.91) 0.90 (0.82–0.98)** 0.85 (0.73–0.97) 0.86 (0.76–0.96)*
Heart rate 0.79 (0.66–0.92) 0.93 (0.88–0.99)* 0.83 (0.70–0.96) 0.86 (0.76–0.95)
CRB-65 0.76 (0.64–0.88) 0.92 (0.86–0.98)** 0.84 (0.71–0.96)* 0.86 (0.78–0.93)**
Van Vught-score 0.76 (0.66–0.87) 0.91 (0.84–0.98)** 0.85 (0.75–0.96)** 0.86 (0.78–0.94)*
PCT 0.88 (0.78–0.98) 0.90 (0.80–0.99) 0.89 (0.79–0.99)
IL-6 0.92 (0.83–1.00) 0.84 (0.72–0.96) 0.87 (0.78–0.96)
sTREM1 0.89 (0.79–0.99) 0.87 (0.78–0.96) 0.83 (0.74–0.92)
  1. Data are area under the receiver-operating characteristic curve and 95% confidence interval
  2. *P < 0.05, **P < 0.01, comparing the clinical parameter AUROC vs the combined clinical parameter with PCT or IL-6 AUROC