Fig. 4

Accuracy of markers of endothelial and immune activation, measured in adults presenting with clinical lower respiratory tract infection to outpatient clinics in predicting bacterial community-acquired pneumonia. Nonparametric ROC curves were generated and AUROC were plotted to illustrate the ability of these markers to discriminate between bacterial community-acquired pneumonia and other lower respiratory tract infection. AUROCs for the outcome of each marker are presented to the right of its respective forest plot, with 95% CIs in parentheses. Angpt-1 angiopoietin-1, Angpt-2 angiopoietin-2, AUROC area under the receiver operating characteristic, CHI3L1 chitinase-3-like protein-1, CI confidence interval, CRP C-reactive protein, IL-6 interleukin-6, IL-8 interleukin-8, IP-10 interferon-gamma-inducible protein-10, PCT procalcitonin, ROC receiver operating characteristic, sICAM-1 soluble intercellular adhesion molecule-1, sTNFR-1 soluble tumour necrosis factor receptor-1, sTREM-1 soluble triggering receptor expressed on myeloid cells, sVCAM-1 soluble vascular cell adhesion molecule-1, sVEGFR1 soluble variant of vascular endothelial growth factor receptor 1