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Fig. 1 | BMC Infectious Diseases

Fig. 1

From: Similar severity of influenza primary and re-infections in pre-school children requiring outpatient treatment due to febrile acute respiratory illness: prospective, multicentre surveillance study (2013–2015)

Fig. 1

Study flow chart. Patients were recruited from outpatient pediatric practices in Bavaria (Germany), 2013–2015. Children aged 1–5 years with febrile acute respiratory infection were enrolled. Patients with PCR-confirmed influenza virus infection were included for the present analyses. Part A Classification of the acute influenza disease as either primary infection or re-infection was defined first on the influenza virus type-level using ELISA to determine influenza A IgG and influenza B IgG serostatus. Part B For patients with acute influenza A infection, in a second approach, primary infection or re-infection were defined on the influenza A virus subtype level using Hemagglutination inhibition (HI) assays to determine subtype-specific IgG serostatus. Note that “influenza A re-infections” defined on the type-level may represent primary infections for a specific influenza A subtype, and if so, are re-classified as either “A(H3N2) primary infection” or “A(H1N1)pdm09 primary infection” for analyses on the subtype level

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BMC Infectious Diseases

ISSN: 1471-2334

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