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Fig. 5 | BMC Infectious Diseases

Fig. 5

From: Rv3737 is required for Mycobacterium tuberculosis growth in vitro and in vivo and correlates with bacterial load and disease severity in human tuberculosis

Fig. 5

Survival of H37RvΔRv3737 and Msm/pMV261-Rv3737 in macrophages and the effects on pro-inflammatory cytokines. A Survival analysis of H37Rv-WT and H37RvΔRv3737 in macrophages. B Survival analysis of Msm/pMV261 and Msm/pMV261-Rv3737 in macrophages. C, D The mRNA levels of TNF-α and IL-6 in macrophages infected with H37Rv-WT and H37RvΔRv3737. Experiments were performed in triplicates. E, F Immunoassays for TNF-α and IL-6 in supernatants collected from macrophages infected with H37Rv-WT and H37RvΔRv3737. The difference between the wild type and the mutant was significant by Student’s t test (*p < 0.05; **p < 0.01; ***p < 0.001)

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BMC Infectious Diseases

ISSN: 1471-2334

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