Definitive antibiotics therapy | All patients n = 314 | Spn susceptible to penicillin n = 84 | Spn not susceptible to penicillin n = 230 | p | ||
---|---|---|---|---|---|---|
 |  |  | Susceptible to cefotaxime n = 95 | Not susceptible to cefotaxime n = 135 | Subtotal n = 230 |  |
Penicillins monotherapy | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | – |
Cephalosporin monotherapy | 39 (12.4) | 19 (22.6) | 18 (18.9) | 2 (1.5) | 20 (8.7) | 0.001 |
Carbapenem monotherapy | 15 (4.8) | 9 (10.7) | 6 (6.3) | 0 (0) | 6 (2.6) | 0.007 |
Cephalosporin plus vancomycin | 88 (28.0) | 18 (21.4) | 26 (27.4) | 44 (32.6) | 70 (30.4) | 0.116 |
Carbapenem plus vancomycin | 94(29.9) | 21 (25.0) | 26 (27.4) | 47 (34.8) | 73 (31.7) | 0.248 |
Cephalosporin plus linezolid | 26 (8.3) | 5 (6.0) | 8 (8.4) | 13 (9.6) | 21 (9.1) | 0.366 |
Carbapenem plus linezolid | 21 (6.7) | 5 (6.0) | 7 (7.4) | 9 (6.7) | 16 (7.0) | 0.753 |
Vancomycin plus rifampin | 16 (5.1) | 5 (6.0) | 2 (2.1) | 9 (6.7) | 11 (4.8) | 0.899 |
Vancomycin monotherapy | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | – |
Linezolid monotherapy | 6 (1.9) | 2 (2.4) | 1 (1.1) | 3 (2.2) | 4 (1.7) | 1.000 |
Other prescriptions | 9 (2.9) | 0 (0) | 1a (1.1) | 8b (5.9) | 9 (3.9) | – |
Inappropriate use of | Â | Â | Â | Â | Â | Â |
 Carbapenems | 133 (42.4) | 35 (41.7) | 40 (42.1) | 58 (43.0) | 98 (42.6) | 0.881 |
 Vancomycin | 109 (34.7) | 54 (64.3) | 55 (57.9) | 0 (0) | 55 (23.9) | 0.000 |
 Linezolid | 28 (8.9) | 12 (14.3) | 16 (16.8) | 0 (0) | 16 (7.0) | 0.044 |
No. patients with inappropriate antibiotic use | 200 (63.7) | 65 (77.4) | 77 (81.1) | 58 (43.0) | 135 (58.7) | 0.002 |