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Table 5 Appropriateness of antibiotic prescription for targeted therapy of meningitis IPD

From: Antibiotics prescription for targeted therapy of pediatric invasive pneumococcal diseases in China: a multicenter retrospective study

Definitive antibiotics therapy All patients
n = 314
Spn susceptible to penicillin
n = 84
Spn not susceptible to penicillin
n = 230
p
    Susceptible to cefotaxime
n = 95
Not susceptible to cefotaxime
n = 135
Subtotal
n = 230
 
Penicillins monotherapy 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
Cephalosporin monotherapy 39 (12.4) 19 (22.6) 18 (18.9) 2 (1.5) 20 (8.7) 0.001
Carbapenem monotherapy 15 (4.8) 9 (10.7) 6 (6.3) 0 (0) 6 (2.6) 0.007
Cephalosporin plus vancomycin 88 (28.0) 18 (21.4) 26 (27.4) 44 (32.6) 70 (30.4) 0.116
Carbapenem plus vancomycin 94(29.9) 21 (25.0) 26 (27.4) 47 (34.8) 73 (31.7) 0.248
Cephalosporin plus linezolid 26 (8.3) 5 (6.0) 8 (8.4) 13 (9.6) 21 (9.1) 0.366
Carbapenem plus linezolid 21 (6.7) 5 (6.0) 7 (7.4) 9 (6.7) 16 (7.0) 0.753
Vancomycin plus rifampin 16 (5.1) 5 (6.0) 2 (2.1) 9 (6.7) 11 (4.8) 0.899
Vancomycin monotherapy 0 (0) 0 (0) 0 (0) 0 (0) 0 (0)
Linezolid monotherapy 6 (1.9) 2 (2.4) 1 (1.1) 3 (2.2) 4 (1.7) 1.000
Other prescriptions 9 (2.9) 0 (0) 1a (1.1) 8b (5.9) 9 (3.9)
Inappropriate use of       
 Carbapenems 133 (42.4) 35 (41.7) 40 (42.1) 58 (43.0) 98 (42.6) 0.881
 Vancomycin 109 (34.7) 54 (64.3) 55 (57.9) 0 (0) 55 (23.9) 0.000
 Linezolid 28 (8.9) 12 (14.3) 16 (16.8) 0 (0) 16 (7.0) 0.044
No. patients with inappropriate antibiotic use 200 (63.7) 65 (77.4) 77 (81.1) 58 (43.0) 135 (58.7) 0.002
  1. Spn, Streptococcus pneumoniae
  2. aCarbapenem plus vancomycin and rifampin
  3. b2 patients with cephalosporin plus vancomycin and rifampin, 2 patients with cephalosporin plus linezolid and rifampin, 2 patients with linezolid plus rifampin, 1 patient with carbapenem plus vancomycin and rifampin and 1 patient with carbapenem plus linezolid and rifampin,