Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis

Table 1 Characteristics of randomized clinical trials included in meta-analysis

	Area	Age	Males (%)	Antibiotic	Oral or topical	Daily dose (mg)	Duration (d)	Follow-up (m)
Costello et al. 1989 [20]	USA	Adults and children	35.7	Penicillin	Oral	1000	10
Shapiro et al. 1992 [21]	USA	Adults and children	42.6	Amoxicillin	Oral	750	10	12^b
Agre et al. 1993 [22]	USA	Children	49.2	Penicillin or tetracycline^a	Oral	1000	10	12–36
Nadelman et al. 2001 [23]	USA	Adults and children	53.3	Doxycycline	Oral	200	1	1.5
Schwameis et al. 2016 [3]	Germany and Austria	Adults	48.7	Azithromyci	Topical	–	3	2
Harms et al. 2021 [9]	Netherlands	Adults and children	50.0	Doxycycline	Oral	200	1	6

^aPatients older than 9 years received tetracycline and those younger than 9 years received penicillin
^bVisit follow-up for 3 months, and telephone follow-up for 12 months

ISSN: 1471-2334