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Table 1 Characteristics of randomized clinical trials included in meta-analysis

From: Antibiotic prophylaxis for prevention against Lyme disease following tick bite: an updated systematic review and meta-analysis

  Area Age Males (%) Antibiotic Oral or topical Daily dose (mg) Duration (d) Follow-up (m)
Costello et al. 1989 [20] USA Adults and children 35.7 Penicillin Oral 1000 10  
Shapiro et al. 1992 [21] USA Adults and children 42.6 Amoxicillin Oral 750 10 12b
Agre et al. 1993 [22] USA Children 49.2 Penicillin or tetracyclinea Oral 1000 10 12–36
Nadelman et al. 2001 [23] USA Adults and children 53.3 Doxycycline Oral 200 1 1.5
Schwameis et al. 2016 [3] Germany and Austria Adults 48.7 Azithromyci Topical 3 2
Harms et al. 2021 [9] Netherlands Adults and children 50.0 Doxycycline Oral 200 1 6
  1. aPatients older than 9 years received tetracycline and those younger than 9 years received penicillin
  2. bVisit follow-up for 3 months, and telephone follow-up for 12 months