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Table 3 Genotypic and allelic frequencies of the TNFA -308G>A and IL10 -1082A>G polymorphisms in relation to the histopathological aspects of chronic HCV carriers

From: TNFA -308G>A and IL10 -1082A>G polymorphisms seem to be predictive biomarkers of chronic HCV infection

Genetic profile Inflammatory activity* Fibrosis score*
0 to 1 2 to 3 p 0 to 2 3 to 4 p
n (%) n (%)   n (%) n (%)  
TNFA -308G>A
 GG 43 (79.6) 30 (83.3) 0.8688 54 (80.6) 28 (82.4) 0.9553
 GA 11 (20.4) 6 (16.7)   13 (19.4) 6 (17.6)  
 AA 0 0   0 0  
 *G 0.90 0.92 0.8048 0.90 0.91 1.000
 *A 0.10 0.08   0.10 0.09  
IL10 -1082A>G
 AA 31 (56.4) 22 (62.9) 0.7530 40 (59.7) 22 (64.7) 0.6839
 AG 20 (36.4) 10 (28.6)   23 (34.3) 9 (26.5)  
 GG 4 (7.2) 3 (8.5)   4 (6.0) 3 (8.8)  
 *A 0.75 0.77 0.8685 0.77 0.78 1.000
 *G 0.25 0.23   0.23 0.22  
  1. *G-test