Table 19 Laboratory outcomes after using antibiotics
From: Inadequate use of antibiotics in the covid-19 era: effectiveness of antibiotic therapy
1 week after admission | No. (Total n = 13,932) | No. (%) | WITH antibiotics n = 12,238 (%) | WITHOUT antibiotics n = 1498 (%) | Odds ratio (95% CI) | p value |
|---|---|---|---|---|---|---|
Anemia (Hb < 12 g/dL) | 12,646 | 3760 (29.7) | 3432 (30.1) | 328 (26.2) | 1.21 (1.06–1.39) | 0.004 |
Thrombocytosis (Platelet count > 180) | 12,631 | 10,191 (80.7) | 9211 (80.9) | 980 (78.5) | 1.16 (1.01–1.34) | 0.036 |
Leukocytosis (Leukocytes > 10,000) | 12,644 | 2401 (19.0) | 2255 (19.8) | 146 (11.7) | 1.87 (1.56–2.23) | < 0.001 |
Leukopenia (Leukocytes < 4000) | 11,150 (88.2) | 10,073 (88.4) | 1,077 (86.2) | 1.22 (1.03–1.45) | 0.020 | |
Lymphopenia (Lymphocytes < 1300) | 12,626 | 4811 (38.1) | 4211 (37.0) | 600 (48.2) | 0.63 (0.56–0.71) | < 0.001 |
Evolution of inflammatory parameters associated with covid-19 | ||||||
 C-reactive protein > 50 mg/L | 12,248 | 4049 (33.1) | 3761 (34.0) | 288 (24.3) | 1.61 (1.40–1.85) | < 0.001 |
 Procalcitonin > 0.5 ng/mL | 4907 | 606 (12.4) | 575 (13.1) | 31 (6.3) | 2.25 (1.55–3.27) | < 0.001 |
 Ferritin > 274 mcg/L | 6149 | 4967 (80.8) | 4506 (81.7) | 461 (73.2) | 1.63 (1.35–1.97) | < 0.001 |
 Fibrinogen > 650 mg/dL | 7852 | 2920 (37.2) | 2602 (37.1) | 318 (38.3) | 0.95 (0.82–1.10) | 0.50 |
 CK > 200 U/L | 5775 | 697 (12.1) | 657 (12.4) | 40 (8.6) | 1.50 (1.08–2.10) | 0.017 |
 LDH > 300 U/L | 11,264 | 5002 (44.4) | 4593 (45.3) | 409 (36.8) | 1.42 (1.25–1.62) | < 0.001 |
 IL-6 > 4.3 pg/mL | 2074 | 1593 (76.8) | 1428 (76.9) | 165 (75.7) | 1.07 (0.77–1.49) | 0.68 |
 D-Dimer > 250 ng/mL | 9605 | 8367 (87.1) | 7570 (87.8) | 797 (81.2) | 1.66 (1.40–1.97) | < 0.001 |