Table 1 Baseline demographic and clinical features of patients with enterococcal bacteremia

Characteristics

Total (n = 37)

Survivors (n = 29)

Non-survivors (n = 8)

P value

Demographics

Age (year, mean±SD)

60.5 ± 13.2

62.8 ± 2.3

52.3 ± 4.4

0.044

BMI (mean±SD)

21.4 ± 3.1

21.2 ± 0.6

22.4 ± 1.1

0.323

Male (%)

22 (59.5)

18(62.1)

4(50.0)

0.412

Community AB (%)

9 (24.3)

7 (24.1)

2 (25.0)

0.643

Hospital AB (%)

28 (75.7)

22 (75.9)

6 (75.0)

0.643

Comorbidities (%)

Solid cancer

21 (56.8)

17 (58.6)

4 (50.0)

0.483

HTN

15 (40.5)

11 (37.9)

4 (50.0)

0.412

DM

13 (35.1)

11 (37.9)

2 (25.0)

0.408

Chronic liver disease

11 (29.7)

8 (27.6)

3 (37.5)

0.444

Organ transplantation

9 (24.3)

7 (24.1)

2 (25.0)

0.643

Chronic renal disease

9 (24.3)

6 (20.7)

3 (37.5)

0.292

Cerebrovascular disease

7 (18.9)

6 (20.7)

1 (12.5)

0.521

Cardiovascular disease

6 (16.2)

5 (17.2)

1 (12.5)

0.613

Hematologic malignancies

4 (10.8)

3 (10.3)

1 (12.5)

0.640

CHF

3 (8.1)

2 (6.9)

1 (12.5)

0.530

Hemiplegia

2 (5.4)

2 (6.9)

0 (0.0)

0.610

PAOD

1 (2.7)

0 (0.0)

1 (12.5)

0.216

ILD

1 (2.7)

1 (3.4)

0 (0.0)

0.784

Antibiotic use in 30 day (%)

27 (73.0)

22 (75.9)

5 (62.5)

0.367

Steroid use in 30 day (%)

16 (43.2)

12 (41.4)

4 (50.0)

0.483

Anticancer drug use in 30 day (%)

9 (24.3)

7 (24.1)

2 (25.0)

0.643

Immunosuppressant use in 30 day (%)

9 (24.3)

7 (24.1)

2 (25.0)

0.643

Vancomycin induced AKI (%)

6 (16.2)

4 (13.8)

2 (25.0)

0.591

Septic shock (%)

8 (21.6)

4 (13.8)

4 (50.0)

0.049

Source of bacteremia (%)

Biliary

15 (40.5)

12 (41.4)

3 (37.5)

0.588

Peritonitis

8 (21.6)

7 (24.1)

1 (12.5)

0.435

UTI

1 (2.7)

0 (0.0)

1 (12.5)

0.216

Skin

1 (2.7)

1 (3.4)

0 (0.0)

0.784

CRBSI

1 (2.7)

1 (3.4)

0 (0.0)

0.784

Foreign device

1 (2.7)

1 (3.4)

0 (0.0)

0.784

Others

2 (5.4)

1 (3.4)

1 (12.5)

0.390

Primary

8 (21.6)

6 (20.7)

2 (25.0)

0.565

ICU stay (%)

14 (37.8)

10 (34.5)

4 (50.0)

0.343

SOFA score (mean±SD)

7.0 ± 4.8

6.2 ± 0.8

9.9 ± 1.9

0.056

Persistent BSI (%)

18 (48.6)

15 (51.7)

3 (37.5)

0.379

Recurrence of same BSI (%)

5 (13.5)

5 (17.2)

0 (0.0)

0.272

Initial empirical inappropriate antibiotics (%)

16 (43.2)

13 (44.8)

3 (37.5)

0.517

Combination therapy (%)

8 (21.6)

6 (20.7)

2 (25.0)

0.565

PK/PD parameter (%)

Trough level ≤15 µg/mL

19 (51.4)

12 (41.4)

7 (87.5)

Trough level>15 µg/mL

18 (48.6)

17 (58.6)

1 (12.5)

0.042

AUC₂₄/MIC≤389

7 (18.9)

5 (17.2)

2 (25.0)

AUC₂₄/MIC>389

30 (81.1)

24 (82.8)

6 (75.0)

0.479

BMI, body mass index; Community AB, Community acquired bacteremia; Hospital AB, Hospital acquired bacteremia; HTN, hypertension; DM, diabetes mellitus; CHF, congestive heart failure; PAOD peripheral arterial occlusive disease; ILD, interstitial lung disease; AKI. Acute kidney disease, UTI, urinary tract infection; CRBSI, catheter-related blood stream infection; BSI, blood stream infection, AUC, area under curve; MIC minimum inhibitory concentration; Other cases of bacteremia include infective endocarditis

Continuous variables are shown as the mean ± standard deviation (SD) and categorical variables, as numbers (percentage)