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Table 1 Characteristics of included studies

From: Plasma leakage in dengue: a systematic review of prospective observational studies

Study Recruitment period Dengue diagnosis* Community (C) or Hospital (H) based Participants Country WHO classification system used Reports DHF/PL/Both
Adil 2020 [8] Sep 2019–Jan 2020 A, S H Adults Pakistan 1997 Both
Alexander 2011 [9] Aug 2006–May 2007 P, S H** Both Thailand, Malaysia, Philippines, Nicaragua, Vietnam, Venezuela, Brazil Both# DHF
Avirutnan 2006 [11] Nov 2001–Dec 2003 A, P H Children Thailand 1997 DHF
Basuki 2010 [12] Oct 2008–Apr 2009 P, S H Children Indonesia Both Both
Biswas 2015 [13] Aug 2005–Jan 2013 S, P, O H** Children Nicaragua Both DHF
Bodinayaka 2018 [14] Not mentioned S, P, O H Both Sri Lanka 2009 PL
Capeding 2015 [15] Nov 2009–Nov 2010 S, P H Children Philippines 1997 DHF
Chattergee 2017 [16] Aug 2013–Jan 2014 A, S H Both India Both DHF
Cordeiro 2007 [17] Feb 2004–2006 A, S, P, O H Both Brazil 1997 DHF
Fariz-Safhan 2014 [18] Jul 2005–Jun 2006 S H Unclear Malaysia 1997, 2002 Both
Guilarde 2008 [19] Jan 2005–Jul 2005 S, P, O H Adults Brazil 1997 DHF
Herath 2019 [20] Aug 2016–Aug 2017 A H Adults Sri Lanka Not used PL
Jagadishkumar 2012 [21] Nov 2008–Jul 2010 S H Children India 1997 DHF
Jain 2017 [22] Aug 2015–Nov 2015 A, S H Adults India 1997 DHF
Kirawittaya 2015 [23] 2010–2012 S, P H Children Thailand Both DHF
Kittigul 2007 [24] Sep 2003–Aug 2004 S H Both Thailand 1997 DHF
Kularatnam 2019 [25] July 2013–April 2014 S H Children Sri Lanka 1997 DHF
Kulasinghe 2016 [26] Apr 2013–Oct 2013 S H Children Sri Lanka   PL***
Laul 2016 [27] Jun 2015–Aug 2015 A, S H Adults India 1997 DHF
Malavige 2006 [29] Apr 2004–Jul 2004 S H Children Sri Lanka 1997 DHF
Malavige 2006 [30] Apr 2004–Jul 2004 S, P H Adults Sri Lanka 1997 DHF
Manamperi 2019 [31] Jan 2017–Dec 2017 A, S H Children Sri Lanka 1997 DHF
Pham 2009 [32] Jul 2007–Oct 2007 P, O H Adults Vietnam Not used PL
Phuong 2004 [33] Jun 1996–Jun 1998 S, O H Children Vietnam 1997 DHF
Poeranto 2016 [34]## 1995–1999 S, P, O H Children Indonesia 1997 DHF
Potts 2010 [47] 1994–2007 S, P, O H Children Thailand 1997 DHF
Prasad 2020 [35] Jul 2014–Jul 2015 S H Children India 2009 PL
Premaratne 2013 [36] Jul 2011–Dec 2011 S H Adults Sri Lanka 1997 PL
Raman 2013 [37] Feb 2011–Nov 2012 S H Adults Bangladesh 1997, 2011 DHF
Seet 2006 [39] Oct 2005–Nov 2005 S H Adults Singapore 1997 DHF
Senaratne 2016 [40] Jul 2011–Feb 2012 S, P H Adults Sri Lanka 1997, 2011 DHF
Sigera 2021 [49] Oct 2017–Feb 2020 A, P H Adults Sri Lanka 2009 PL
Suwarto 2016 [41] Mar 2010–Aug 2015 A, P H Adults Indonesia Not used PL
Tang 2008 [48] Aug 2006–Oct 2006 S H Both China 1997 DHF
Taylor 2015 [42] Sep 2008–Nov 2008 A, S, P H Adults Vietnam 2009 PL
Thomas 2012 [43] Jan 2005–Dec 2010 S, P H Adults Martinique (France) Both Both
Trung 2012[50] Sep 2006 – Sep 2008 A, S, P H Both Vietnam 1997 PL###
Vasanwala 2014 [44] Jan 2012–Aug 2012 A, P H Adults Singapore 1997 DHF
Yacoub 2017 [45] Jun 2013–Oct 2015 A, S, P H Both Vietnam 2009 PL
Yung 2015 [46] Apr 2005–Dec 2011 A, S, P H Adults Singapore Both DHF
Anderson 2011 [10] Jan 1998–2002 P, S C Children Thailand 1997 DHF
L’Azou 2016 [28] Jun 2011–Apr 2014 A, P C Children Indonesia, Malaysia, Philippines, Thailand, Vietnam, Brazil, Honduras, Mexico, Puerto Rico, Colombia 1997 DHF
Sabchareon 2012 [38] Feb 2006–2009 S, P, O C Children Thailand 1997 DHF
  1. *NS1 antigen test (A), RT-PCR (P), Serology—IgM or IgG and IgM combination or paired IgG analysis only (S), Other—viral isolation (O), **Mentions that some patients were managed as outpatients and proportion of in-patient DHF patients were extracted or calculated, for other studies all patients were assumed have been managed as in-patients, ***diagnosis of “DHF” was synonymous with plasma leakage, #Primary study for 2009 WHO dengue classification, ##Reclassification of a previous cohort, ###This study provides the number of patients with a haematocrit rise > 20%, rather than plasma leakage