Plasma leakage in dengue: a systematic review of prospective observational studies

Rodrigo, Chaturaka; Sigera, Chathurani; Fernando, Deepika; Rajapakse, Senaka

doi:10.1186/s12879-021-06793-2

BMC Infectious Diseases

Table 1 Characteristics of included studies

From: Plasma leakage in dengue: a systematic review of prospective observational studies

Study	Recruitment period	Dengue diagnosis*	Community (C) or Hospital (H) based	Participants	Country	WHO classification system used	Reports DHF/PL/Both
Adil 2020 [8]	Sep 2019–Jan 2020	A, S	H	Adults	Pakistan	1997	Both
Alexander 2011 [9]	Aug 2006–May 2007	P, S	H**	Both	Thailand, Malaysia, Philippines, Nicaragua, Vietnam, Venezuela, Brazil	Both^#	DHF
Avirutnan 2006 [11]	Nov 2001–Dec 2003	A, P	H	Children	Thailand	1997	DHF
Basuki 2010 [12]	Oct 2008–Apr 2009	P, S	H	Children	Indonesia	Both	Both
Biswas 2015 [13]	Aug 2005–Jan 2013	S, P, O	H**	Children	Nicaragua	Both	DHF
Bodinayaka 2018 [14]	Not mentioned	S, P, O	H	Both	Sri Lanka	2009	PL
Capeding 2015 [15]	Nov 2009–Nov 2010	S, P	H	Children	Philippines	1997	DHF
Chattergee 2017 [16]	Aug 2013–Jan 2014	A, S	H	Both	India	Both	DHF
Cordeiro 2007 [17]	Feb 2004–2006	A, S, P, O	H	Both	Brazil	1997	DHF
Fariz-Safhan 2014 [18]	Jul 2005–Jun 2006	S	H	Unclear	Malaysia	1997, 2002	Both
Guilarde 2008 [19]	Jan 2005–Jul 2005	S, P, O	H	Adults	Brazil	1997	DHF
Herath 2019 [20]	Aug 2016–Aug 2017	A	H	Adults	Sri Lanka	Not used	PL
Jagadishkumar 2012 [21]	Nov 2008–Jul 2010	S	H	Children	India	1997	DHF
Jain 2017 [22]	Aug 2015–Nov 2015	A, S	H	Adults	India	1997	DHF
Kirawittaya 2015 [23]	2010–2012	S, P	H	Children	Thailand	Both	DHF
Kittigul 2007 [24]	Sep 2003–Aug 2004	S	H	Both	Thailand	1997	DHF
Kularatnam 2019 [25]	July 2013–April 2014	S	H	Children	Sri Lanka	1997	DHF
Kulasinghe 2016 [26]	Apr 2013–Oct 2013	S	H	Children	Sri Lanka		PL***
Laul 2016 [27]	Jun 2015–Aug 2015	A, S	H	Adults	India	1997	DHF
Malavige 2006 [29]	Apr 2004–Jul 2004	S	H	Children	Sri Lanka	1997	DHF
Malavige 2006 [30]	Apr 2004–Jul 2004	S, P	H	Adults	Sri Lanka	1997	DHF
Manamperi 2019 [31]	Jan 2017–Dec 2017	A, S	H	Children	Sri Lanka	1997	DHF
Pham 2009 [32]	Jul 2007–Oct 2007	P, O	H	Adults	Vietnam	Not used	PL
Phuong 2004 [33]	Jun 1996–Jun 1998	S, O	H	Children	Vietnam	1997	DHF
Poeranto 2016 [34]^##	1995–1999	S, P, O	H	Children	Indonesia	1997	DHF
Potts 2010 [47]	1994–2007	S, P, O	H	Children	Thailand	1997	DHF
Prasad 2020 [35]	Jul 2014–Jul 2015	S	H	Children	India	2009	PL
Premaratne 2013 [36]	Jul 2011–Dec 2011	S	H	Adults	Sri Lanka	1997	PL
Raman 2013 [37]	Feb 2011–Nov 2012	S	H	Adults	Bangladesh	1997, 2011	DHF
Seet 2006 [39]	Oct 2005–Nov 2005	S	H	Adults	Singapore	1997	DHF
Senaratne 2016 [40]	Jul 2011–Feb 2012	S, P	H	Adults	Sri Lanka	1997, 2011	DHF
Sigera 2021 [49]	Oct 2017–Feb 2020	A, P	H	Adults	Sri Lanka	2009	PL
Suwarto 2016 [41]	Mar 2010–Aug 2015	A, P	H	Adults	Indonesia	Not used	PL
Tang 2008 [48]	Aug 2006–Oct 2006	S	H	Both	China	1997	DHF
Taylor 2015 [42]	Sep 2008–Nov 2008	A, S, P	H	Adults	Vietnam	2009	PL
Thomas 2012 [43]	Jan 2005–Dec 2010	S, P	H	Adults	Martinique (France)	Both	Both
Trung 2012[50]	Sep 2006 – Sep 2008	A, S, P	H	Both	Vietnam	1997	PL^###
Vasanwala 2014 [44]	Jan 2012–Aug 2012	A, P	H	Adults	Singapore	1997	DHF
Yacoub 2017 [45]	Jun 2013–Oct 2015	A, S, P	H	Both	Vietnam	2009	PL
Yung 2015 [46]	Apr 2005–Dec 2011	A, S, P	H	Adults	Singapore	Both	DHF
Anderson 2011 [10]	Jan 1998–2002	P, S	C	Children	Thailand	1997	DHF
L’Azou 2016 [28]	Jun 2011–Apr 2014	A, P	C	Children	Indonesia, Malaysia, Philippines, Thailand, Vietnam, Brazil, Honduras, Mexico, Puerto Rico, Colombia	1997	DHF
Sabchareon 2012 [38]	Feb 2006–2009	S, P, O	C	Children	Thailand	1997	DHF

*NS1 antigen test (A), RT-PCR (P), Serology—IgM or IgG and IgM combination or paired IgG analysis only (S), Other—viral isolation (O), **Mentions that some patients were managed as outpatients and proportion of in-patient DHF patients were extracted or calculated, for other studies all patients were assumed have been managed as in-patients, ***diagnosis of “DHF” was synonymous with plasma leakage, ^#Primary study for 2009 WHO dengue classification, ^##Reclassification of a previous cohort, ^###This study provides the number of patients with a haematocrit rise > 20%, rather than plasma leakage

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