Application of mNGS to describe the clinical and microbial characteristics of severe burn a tanker explosion at a tertiary medical center: a retrospective study patients following

Table 5 Estimated potential impact of mNGS testing on application of antimicrobial agents in patients with severe burn patients (n = 71)

Modifications	Antimicrobial agents	N (%)
De-escalation		6 (8.5)
Antifungal	Remove VCZ	2
Antifungal	Reduce AmB to CAS	1
Against Gram-negative bacilli	Reduce MEM to SCF	2
Against Gram-negative bacilli	Reduce SCF to CAZ	1
Escalation		29 (40.8)
Antifungal	Add VCZ	5
	Add AmB	4
	Add CAS	2
Against Gram-negative bacilli	Add polymyxin B	3
	Add TGC	4
	Add ceftazidime and avibactam	2
	Add AmK	1
	Add MEM	2
	Add TGC + MEM	1
Against Gram-postive bacilli	Add VAN	2
Against Gram-postive bacilli	Add LZD	3
No change		36 (50.7)

VCZ voriconazole, AmB amphotericin B, CAS caspofungin, MEM meropenem, SCF sulbactam and cefoperazone, CAZ ceftazidime, TGC tigecycline, AmK amikacin, VAN vancomycin, LZD linezolid

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