Table 4 Meta-regression analyses of sensitivity and specificity
From: Serum CA-125 for the diagnosis of pulmonary tuberculosis: a systematic review and meta-analysis
Parameter | Category | Number of studies | Sensitivity (95% CI) | P1 | Specificity (95% CI) | P2 |
|---|---|---|---|---|---|---|
Q1 | Yes | 14 | 0.87 (0.81–0.94) | 0.08 | 0.89 (0.82–0.95) | 0.36 |
Uncertain | 2 | 0.53 (0.18–0.88) | 0.73 (0.42–1.00) | |||
Q2 | Yes | 8 | 0.80 (0.67–0.93) | 0.06 | 0.73 (0.64–0.82) | < 0.001* |
No | 8 | 0.88 (0.79–0.97) | 0.94 (0.90–0.98) | |||
Q3 | Yes | 9 | 0.81 (0.69–0.94) | 0.09 | 0.89 (0.81–0.97) | 0.51 |
No | 7 | 0.88 (0.78–0.98) | 0.84 (0.73–0.96) | |||
Q5 | Yes | 6 | 0.74 (0.57–0.91) | 0.01* | 0.81 (0.67–0.96) | 0.04* |
No | 10 | 0.89 (0.82–0.96) | 0.90 (0.83–0.97) | |||
Q8 | Yes | 6 | 0.78 (0.62–0.94) | 0.06 | 0.86 (0.75–0.98) | 0.26 |
Uncertain | 10 | 0.88 (0.80–0.96) | 0.88 (0.79–0.96) | |||
Country | Yes | 8 | 0.82 (0.69–0.94) | 0.11 | 0.87 (0.77–0.97) | 0.24 |
No | 8 | 0.88 (0.78–0.97) | 0.88 (0.78–0.97) | |||
Q11 | Yes | 5 | 0.87 (0.75–0.99) | 0.61 | 0.87 (0.76–0.99) | 0.39 |
No | 11 | 0.83 (0.73–0.94) | 0.87 (0.78–0.96) | |||
Language | Yes | 10 | 0.89 (0.81–0.96) | 0.90 | 0.88 (0.80–0.97) | 0.53 |
No | 6 | 0.76 (0.60–0.93) | 0.85 (0.72–0.98) | |||
Method | Yes | 8 | 0.82 (0.69–0.94) | 0.11 | 0.87 (0.77–0.97) | 0.24 |
No | 8 | 0.88 (0.78–0.97) | 0.88 (0.78–0.97) | |||
M-age | Yes | 10 | 0.78 (0.66–0.90) | < 0.001* | 0.83 (0.73–0.93) | 0.03* |
No | 6 | 0.92 (0.86–0.99) | 0.92 (0.85–1.00) |