Table 2 Main characteristics of studies included in the meta-analysis
From: Serum CA-125 for the diagnosis of pulmonary tuberculosis: a systematic review and meta-analysis
No. | Author | Country | Year | TP | FP | FN | TN | No. of Cases | Cut-off (U/ml) | Control | Golden standard | Language | Method | Age of cases | M/F |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Du [14] | China | 2014 | 100 | 10 | 19 | 26 | 119 | 35.00 | Other respiratory disease | Clinical, radiological or bacteriological findings | Chinese | ECLIA | 41 (22–78) | 60/59 |
2 | Du [7] | China | 2017 | 87 | 2 | 15 | 46 | 102 | 13.60 | Healthy individuals | Positive culture for Mtb in sputum | English | ECLIA | 49.03 ± 3.23 | 77/25 |
3 | Fortún [15] | Spain | 2009 | 24 | 12 | 11 | 42 | 35 | 32.50 | Other respiratory disease | Positive culture for Mtb in sputum or other tract respiratory samples | English | RIA | − | − |
4 | Liang [16] | China | 2014 | 21 | 0 | 22 | 20 | 43 | 35.15 | Heath individuals | Clinical, radiological or bacteriological findings | Chinese | ECLIA | 45.27 ± 2.81 | 24/19 |
5 | Liu [17] | China | 2009 | 93 | 4 | 3 | 39 | 96 | 35.00 | Inactive tuberculosis | Sputum smear positive for AFB or positive culture for Mtb | Chinese | ECLIA | 52 ± 19 | 75/21 |
6 | Ma [18] | China | 2016 | 108 | 68 | 5 | 384 | 113 | 10.30 | Heath individuals | Clinical, radiological and bacteriological findings | English | ECLIA | 38.16 ± 18.86§; 52.18 ± 21.22¶ | 72/41 |
7 | Mikačić [19] | Bosnia and Herzegovina | 2017 | 30 | 59 | 10 | 121 | 40 | 35.00 | Other respiratory disease | Positive culture for Mtb in sputum | English | CMIA | 65 (18–89)* | 163/57# |
8 | Mohammad [20] | Egypt | 2016 | 33 | 11 | 7 | 29 | 40 | 21.05 | Heath individuals and other respiratory disease | Clinical, radiological and bacteriological findings | English | ELISA | 34.2 ± 15.15 | 35/5 |
9 | Ozsahin [21] | Turkey | 2008 | 19 | 48 | 11 | 68 | 30 | 35.00 | Inactive tuberculosis and other respiratory disease | Sputum smear positive for AFB or positive culture for Mtb | English | MEIA | 54 ± 15 | − |
10 | Rizk [22] | Egypt | 2018 | 40 | 5 | 2 | 22 | 42 | 37.60 | Other respiratory disease | Clinical, radiological and bacteriological findings | English | ELISA | 40.190 ± 13.095 | 33/9 |
11 | Şahin [23] | Turkey | 2012 | 41 | 0 | 1 | 55 | 42 | 36.35 | Heath individuals and inactive tuberculosis | Sputum smear positive for AFB and positive culture for Mtb | English | MEIA | 35.62 ± 9.48 | 26/16 |
12 | Said [24] | Egypt | 2013 | 22 | 1 | 5 | 19 | 27 | 34.60 | Healthy individuals | Clinical, radiological and bacteriological findings | English | ELFA | 36.5 (15–70) | 14/13 |
13 | Sun [25] | China | 2019 | 37 | 197 | 6 | 449 | 43 | 22.00 | Other respiratory disease | Clinical, radiological or bacteriological findings | Chinese | ECLIA | 60.4 ± 22.1 | − |
14 | Xu [26] | China | 2013 | 29 | 12 | 15 | 66 | 44 | 30.25 | Community acquired pneumonia | Clinical, radiological or bacteriological findings | Chinese | ECLIA | 58 | 19/25 |
15 | Yilmaz [6] | Turkey | 2001 | 39 | 0 | 1 | 56 | 40 | 31.00 | Heath individuals and inactive tuberculosis | Sputum smear positive for AFB and positive culture for Mtb | English | RIA | 29.1 (16–60) | 34/6 |
16 | Yuan [27] | China | 2015 | 26 | 5 | 34 | 27 | 60 | 35.00 | Heath individuals | Clinical, radiological or bacteriological findings | Chinese | ECLIA | 48 (18–72) | 32/28 |