Skip to main content

Table 2 Main characteristics of studies included in the meta-analysis

From: Serum CA-125 for the diagnosis of pulmonary tuberculosis: a systematic review and meta-analysis

No. Author Country Year TP FP FN TN No. of Cases Cut-off (U/ml) Control Golden standard Language Method Age of cases M/F
1 Du [14] China 2014 100 10 19 26 119 35.00 Other respiratory disease Clinical, radiological or bacteriological findings Chinese ECLIA 41 (22–78) 60/59
2 Du [7] China 2017 87 2 15 46 102 13.60 Healthy individuals Positive culture for Mtb in sputum English ECLIA 49.03 ± 3.23 77/25
3 Fortún [15] Spain 2009 24 12 11 42 35 32.50 Other respiratory disease Positive culture for Mtb in sputum or other tract respiratory samples English RIA
4 Liang [16] China 2014 21 0 22 20 43 35.15 Heath individuals Clinical, radiological or bacteriological findings Chinese ECLIA 45.27 ± 2.81 24/19
5 Liu [17] China 2009 93 4 3 39 96 35.00 Inactive tuberculosis Sputum smear positive for AFB or positive culture for Mtb Chinese ECLIA 52 ± 19 75/21
6 Ma [18] China 2016 108 68 5 384 113 10.30 Heath individuals Clinical, radiological and bacteriological findings English ECLIA 38.16 ± 18.86§; 52.18 ± 21.22 72/41
7 Mikačić [19] Bosnia and Herzegovina 2017 30 59 10 121 40 35.00 Other respiratory disease Positive culture for Mtb in sputum English CMIA 65 (18–89)* 163/57#
8 Mohammad [20] Egypt 2016 33 11 7 29 40 21.05 Heath individuals and other respiratory disease Clinical, radiological and bacteriological findings English ELISA 34.2 ± 15.15 35/5
9 Ozsahin [21] Turkey 2008 19 48 11 68 30 35.00 Inactive tuberculosis and other respiratory disease Sputum smear positive for AFB or positive culture for Mtb English MEIA 54 ± 15
10 Rizk [22] Egypt 2018 40 5 2 22 42 37.60 Other respiratory disease Clinical, radiological and bacteriological findings English ELISA 40.190 ± 13.095 33/9
11 Şahin [23] Turkey 2012 41 0 1 55 42 36.35 Heath individuals and inactive tuberculosis Sputum smear positive for AFB and positive culture for Mtb English MEIA 35.62 ± 9.48 26/16
12 Said [24] Egypt 2013 22 1 5 19 27 34.60 Healthy individuals Clinical, radiological and bacteriological findings English ELFA 36.5 (15–70) 14/13
13 Sun [25] China 2019 37 197 6 449 43 22.00 Other respiratory disease Clinical, radiological or bacteriological findings Chinese ECLIA 60.4 ± 22.1
14 Xu [26] China 2013 29 12 15 66 44 30.25 Community acquired pneumonia Clinical, radiological or bacteriological findings Chinese ECLIA 58 19/25
15 Yilmaz [6] Turkey 2001 39 0 1 56 40 31.00 Heath individuals and inactive tuberculosis Sputum smear positive for AFB and positive culture for Mtb English RIA 29.1 (16–60) 34/6
16 Yuan [27] China 2015 26 5 34 27 60 35.00 Heath individuals Clinical, radiological or bacteriological findings Chinese ECLIA 48 (18–72) 32/28
  1. TP true positive; FP false positive; FN false negative; TN false negative; ECLIA Electrochemiluminescence immunoassay; RIA radioimmunoassay; CMIA chemoluminescent micro particle immunoassay; ELISA enzyme linked immunosorbent assay; MEIA microparticle enzyme immunoassay; ELFA enzyme linked fluorescent assay; M/F male/female; − no data
  2. §Average age of initial treatment patients
  3. Average age of retreatment patients
  4. *Mean age and range of all participants
  5. #M/F of all participants