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Table 2 rpoB mutations found among culture-positive phenotypic RIF-susceptible cases

From: Molecular characterization of rpoB gene mutations in isolates from tuberculosis patients in Cubal, Republic of Angola

Frequency

 

Culture-based DST

(MGIT 960)

MIC

(MGIT 960)

GenoType MTBDRplus

Sequencing

INH

RIF

RIF

rpoB

katG

inhA

rpoB

176

C1

S

S

Not done

wt pattern

wt pattern

wt pattern

Not done

10

C1

R

S

Not done

wt pattern

∆wt, S315T1

wt pattern

Not done

1

C1

R

S

Not done

wt pattern

∆wt

wt pattern

Not done

2

C1

R

S

Not done

wt pattern

wt pattern

∆wt1, C15T

Not done

13

C1

R

S

Not done

wt pattern

wt pattern

wt pattern

Not done

1

C1

R

S

0.125

∆wt2

∆wt, S315T1

wt pattern

L430P (+)

1

C1

R

S

0.125

∆wt7

wt pattern

wt pattern

H445N (+)

1

C1

R

S

0.5

∆wt7

∆wt, S315T1

wt pattern

H445L (+++)

15

C2

S

S

Not done

wt pattern

wt pattern

wt pattern

Not done

1

C2

R

S

Not done

wt pattern

∆wt, S315T1

wt pattern

Not done

1

C2

R

S

Not done

wt pattern

wt pattern

wt pattern

Not done

2

C2

R

S

0.5

∆wt3,4

∆wt, S315T1

wt pattern

D435Y (++)

1

C2

R

S

1.0

∆wt7

∆wt

wt pattern

H445L (+++)

1

C2

R

S

0.5

∆wt8

∆wt, S315T1

wt pattern

L452P (++)

1

C2

R

S

No viable

∆wt8

∆wt

wt pattern

L452P (++)

  1. DST drug susceptibility testing; MIC minimum inhibitory concentration; C1 new cases; C2 previously treated cases
  2. WT1 (424–428), WT2 (429–432), WT3 (429–436), WT4 (435–438), WT5 (437–441), WT6 (441–444), WT7 (445–448), WT8 (449–452)
  3. (+++) high confidence for association with resistance, (++) moderate confidence for association with resistance, (+) minimal confidence for association with resistance