Associations between YKL-40 and markers of disease severity and death in patients with necrotizing soft-tissue infection

Table 2 Univariate and multivariate logistic regression analyses of 30-day mortality based on plasma YKL-40 concentration at admission according to the median and optimal cut-off values

	Plasma YKL-40 ng/mL	Unadjusted			Adjusted analysis: age, sex and comorbidity^a			Adjusted analysis: sex, comorbidity and SAPS II^b
		OR	95% CI	P	OR	95% CI	P	OR	95% CI	P
Median	< 1191		1 (Reference)			1 (Reference)			1 (Reference)
Median	≥ 1191	3.00	1.27–7.69	0.02	3.13	1.30–8.19	0.01	1.45	0.51–4.24	0.49
Optimal	< 1840		1 (Reference)			1 (Reference)			1 (Reference)
Optimal	≥ 1840	3.55	1.55–8.48	0.003	3.77	1.59–9.24	0.003	1.75	0.62–4.89	0.29

CI confidence interval, OR odds ratio, SAPS II simplified acute physiology score II (data were missing for 4 (2%) patients, all survivors, these patients were excluded from the analyses)
^aComorbidity dichotomized (yes/no)
^bAge included in SAPS II score