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Table 1 Characteristics of patients with necrotizing soft-tissue infection

From: Associations between YKL-40 and markers of disease severity and death in patients with necrotizing soft-tissue infection

  Entire cohort (n = 161)
Demographics  
Age, years 61 (53–69)
Sex, male 98 (61)
Body mass index, kg/m2 26 (24–31)
Comorbidities  
Cardiovascular disease 75 (47)
Chronic kidney disease 13 (8)
COPD 17 (11)
Diabetes 40 (25)
Immune deficiency 12 (7)
Chronic liver disease 9 (6)
Malignancy 14 (9)
Peripheral vascular disease 21 (13)
Rheumatoid disease 11 (7)
No comorbidities 49 (30)
Pre-existing conditions  
Active smokera 49 (30)
High alcohol consumptionb 23 (14)
Steroid treatment 21 (13)
Immunosuppressing drugs 15 (9)
Biochemistry  
Leukocyte count, 109/L 16.2 (11.4–22.7)
C-reactive protein, mg/L 224 (153–309)
Procalcitonin, µg/L 8.6 (2.1–37.1)
Creatinine, µmol/L 121 (79–307)
Lactate, mmol/L 2.3 (1.3–4.7)
Other  
SOFA scorec 8 (6–11)
SAPS IId 45 (35–54)
Septic shocke 80 (50)
ICU length of stay, daysf 7 (4–13)
Amputation within 7 daysg 27 (17)
RRT within 7 days 35 (22)
30-day mortality, n (%, 95% CI) 28 (17, 12–24)
90-day mortality, n (%, 95% CI) 37 (23, 17–30)
  1. Continuous data are presented as medians (interquartile range, IQR) and categorial data as absolute numbers (percentage, %)
  2. COPD chronic obstructive pulmonary disease, ICU intensive care unit, RRT renal replacement therapy
  3. aData were missing for 38 (24%) patients. bHigh alcohol consumption defined as > 14 units of alcohol/week (female); > 21 units of alcohol/week (male), data were missing for 43 (27%) patients. cSequential Organ Failure Assessment (SOFA) Score (Day 1); data were missing for 3 (2%) patients. dSimplified Acute Physiology Score II (SAPS II); data were missing for 4 (2%) patients. eFrom the first 24 h after admission. Septic shock defined as lactate > 2 mmol/l and use of vasopressor or inotrope. fTotal ICU length of stay including patients subsequently transferred to ICUs in other hospitals. g1 (50%) patients had NSTI on an extremity