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Table 3 Clinical appearance of EM patients with or without exposition to other tick-borne agents

From: Tick-transmitted co-infections among erythema migrans patients in a general practice setting in Norway: a clinical and laboratory follow-up study

  EM with possible co-infection (n = 16) EM without co-infection (n = 119) p-value
  Statistics n Statistics N  
Female, n (%) 8 (50%) 16 73 (61%) 118 0.36e
Age, mean (SD) 53.6 (20.7) 16 54.7 (15.3) 119 0.79f
Days from tick-bite to EM, median (IQR) 21 (8–25) 11 11 (5–21) 74 0.21g
Days from EM to treatment, median (IQR) 5 (2–20) 15 7 (2–16) 103 0.87g
Diagnostic accuracy “very sure”a, n (%) 12 (75%) 16 81 (68%) 119 0.78h
EM duration, median (IQR) 14 (8–28) 16 14 (9–21) 119 0.66g
Concomitant symptomsb, median (IQR) 2 (0–3) 16 1 (0–2) 119 0.50g
Fever, n (%) 1 (6.3%) 16 4 (3.4%) 117 0.48h
EM colorc, mean (SD) 3.6 (0.89) 16 3.27 (0.89) 119 0.13f
EM diameter (cm), median (IQR) 10 (6–11) 16 10 (7–14) 116 0.69g
EM appearance “Bulls eye”, n (%) 11 (69%) 16 59 (50%) 117 0.16e
Bbsl biopsy pos., n (%) 12 (86%) 14 58 (66%) 88 0.22h
Antibiotic treatmentd, n (%) A: 2 (13%)
B: 5 (31%)
C: 9 (56%)
16 A: 38 (32%)
B: 41 (34%)
C: 40 (34%)
119 N/A
  1. IQR  interquartile range, SD  standard deviation
  2. aDiagnostic accuracy scored by including GP, “not sure”, “sure” or “very sure”
  3. bNumber of the 16 symptoms registered: Tiredness, headache, arthralgia, neck stiffness, fever, palpitations, myalgia, sore throat, tender skin, dizziness, nausea, chest pain, diarrhea, chills, hot flushes, coughing
  4. cColour of the EM at the day of inclusion, grade 1–5 (light red—dark red).
  5. dA = phenoxymethylpenicillin, B = Amoxicillin. C = Doxycycline. Treatments were randomized in the trial [19].
  6. eX2-test
  7. ft-test
  8. gMann–Whitney U test
  9. hFisher’s Exact Test