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Table 3 Clinical appearance of EM patients with or without exposition to other tick-borne agents

From: Tick-transmitted co-infections among erythema migrans patients in a general practice setting in Norway: a clinical and laboratory follow-up study

 

EM with possible co-infection (n = 16)

EM without co-infection (n = 119)

p-value

 

Statistics

n

Statistics

N

 

Female, n (%)

8 (50%)

16

73 (61%)

118

0.36e

Age, mean (SD)

53.6 (20.7)

16

54.7 (15.3)

119

0.79f

Days from tick-bite to EM, median (IQR)

21 (8–25)

11

11 (5–21)

74

0.21g

Days from EM to treatment, median (IQR)

5 (2–20)

15

7 (2–16)

103

0.87g

Diagnostic accuracy “very sure”a, n (%)

12 (75%)

16

81 (68%)

119

0.78h

EM duration, median (IQR)

14 (8–28)

16

14 (9–21)

119

0.66g

Concomitant symptomsb, median (IQR)

2 (0–3)

16

1 (0–2)

119

0.50g

Fever, n (%)

1 (6.3%)

16

4 (3.4%)

117

0.48h

EM colorc, mean (SD)

3.6 (0.89)

16

3.27 (0.89)

119

0.13f

EM diameter (cm), median (IQR)

10 (6–11)

16

10 (7–14)

116

0.69g

EM appearance “Bulls eye”, n (%)

11 (69%)

16

59 (50%)

117

0.16e

Bbsl biopsy pos., n (%)

12 (86%)

14

58 (66%)

88

0.22h

Antibiotic treatmentd, n (%)

A: 2 (13%)

B: 5 (31%)

C: 9 (56%)

16

A: 38 (32%)

B: 41 (34%)

C: 40 (34%)

119

N/A

  1. IQR  interquartile range, SD  standard deviation
  2. aDiagnostic accuracy scored by including GP, “not sure”, “sure” or “very sure”
  3. bNumber of the 16 symptoms registered: Tiredness, headache, arthralgia, neck stiffness, fever, palpitations, myalgia, sore throat, tender skin, dizziness, nausea, chest pain, diarrhea, chills, hot flushes, coughing
  4. cColour of the EM at the day of inclusion, grade 1–5 (light red—dark red).
  5. dA = phenoxymethylpenicillin, B = Amoxicillin. C = Doxycycline. Treatments were randomized in the trial [19].
  6. eX2-test
  7. ft-test
  8. gMann–Whitney U test
  9. hFisher’s Exact Test