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Table 6 Clinical characteristics of pulmonary and extrapulmonary cryptococcosis patients

From: Clinical features of cryptococcosis in patients with different immune statuses: a multicenter study in Jiangsu Province–China

  Pulmonary N = 198 (%) Extrapulmonary N = 57 (%) P value
Site
 Only skin 1/57 (1.8)  
 Only bloodstream 5/57 (8.8)  
 Only CNS 42/57 (73.7)  
 Bloodstream and CNS 9/57 (15.8)  
Laboratory test indicators
 LY (*109/L) 2.0 ± 0.8 1.0 ± 0.9  < 0.001
CSF CrAg (meningitis) 44/45 (97.8)  
Serum CrAg 105/132 (79.5) 23/23 (100.0) 0.015
Symptom
 Asymptomatic 54 (27.3) 5 (8.8) 0.005
 Fever 28 (14.1) 43 (75.4)  < 0.001
 Headache/dizziness 6 (3.0) 45 (79.0)  < 0.001
 Meningeal irritation 0 6 (10.5)  < 0.001
Medical history
 Mild-to-moderate immunodeficiency 34 (17.2) 9 (15.9) 0.806
 Severe immunodeficiency 1246 (6.1) 3140 (54.4)  < 0.001
 Glucocorticoid 17 (8.6) 25 (43.9)  < 0.001
 Immunosuppressants 10 (5.1) 21 (36.8)  < 0.001
 Autoimmune-related diseases 6 (3.0) 12 (21.1)  < 0.001
 Kidney transplant 4 (2.0) 9 (15.8)  < 0.001
 AIDS 1 (0.5) 7 (10.5)  < 0.001
 Diabetes 20 (10.1) 5 (8.7) 0.766
 APACHE II, median (IQR) 2.0 (1.0, 5.0) 7.0 (3.5, 10.8)  < 0.001
  1. CNS, central nervous system; LY, lymphocyte