Table 6 Clinical characteristics of pulmonary and extrapulmonary cryptococcosis patients

Site

 Only skin

–

1/57 (1.8)

 Only bloodstream

–

5/57 (8.8)

 Only CNS

–

42/57 (73.7)

 Bloodstream and CNS

–

9/57 (15.8)

Laboratory test indicators

 LY (*10⁹/L)

2.0 ± 0.8

1.0 ± 0.9

 < 0.001

CSF CrAg (meningitis)

–

44/45 (97.8)

Serum CrAg

105/132 (79.5)

23/23 (100.0)

0.015

Symptom

 Asymptomatic

54 (27.3)

5 (8.8)

0.005

 Fever

28 (14.1)

43 (75.4)

 < 0.001

 Headache/dizziness

6 (3.0)

45 (79.0)

 < 0.001

 Meningeal irritation

0

6 (10.5)

 < 0.001

Medical history

 Mild-to-moderate immunodeficiency

34 (17.2)

9 (15.9)

0.806

 Severe immunodeficiency

1246 (6.1)

3140 (54.4)

 < 0.001

 Glucocorticoid

17 (8.6)

25 (43.9)

 < 0.001

 Immunosuppressants

10 (5.1)

21 (36.8)

 < 0.001

 Autoimmune-related diseases

6 (3.0)

12 (21.1)

 < 0.001

 Kidney transplant

4 (2.0)

9 (15.8)

 < 0.001

 AIDS

1 (0.5)

7 (10.5)

 < 0.001

 Diabetes

20 (10.1)

5 (8.7)

0.766

 APACHE II, median (IQR)

2.0 (1.0, 5.0)

7.0 (3.5, 10.8)

 < 0.001