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Table 3 Microbiological outcomes

From: Combination antibiotic therapy versus monotherapy in the treatment of acute exacerbations of chronic obstructive pulmonary disease: an open-label randomized trial

End Point No. success (%) Monotherapy (n = 79) Combination therapy (n = 60) P-value
Overall success, no. (%) 128 (92.1) 70 (88.6) 58 (96.7) 0.11
Success per pathogen
 Streptococcus pneumoniae (n = 50) 48 31/32 (96.9) 17/18 (94.4) 1
 Haemophilus influenzae (n = 29) 27 20/21 (95.2) 7/8 (87.5) 0.48
 Pseudomonas aeruginosa (n = 18) 16 1/3 (33.3) 15/15 (100) 0.01
 Acinetobacter baumanii (n = 12) 8 1/5 (20.0) 7/7 (100) 0.01
 Stenotrophomonas maltophilia (n = 10) 9 5/6 (100) 4/4 (100) 1
 Staphylococcus aureus (n = 8) 8 4/4 (100) 4/4 (100) 1
 Escherichia coli (n = 6) 6 4/4 (100) 2/2 (100) 1
 Moraxella catarrhalis (n = 6) 6 4/4 (100) 2/2 (100) 1
  1. A potential pathogen was identified in 128 exacerbations